Comparative Pharmacology
Head-to-head clinical analysis: E Z CAT DRY versus E Z HD.
Peer-Reviewed Evidence
Head-to-head clinical analysis: E Z CAT DRY versus E Z HD.
E-Z-CAT DRY vs E-Z-HD
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
E-Z-CAT DRY is a barium sulfate suspension used as a radiographic contrast agent. It does not have a pharmacological mechanism of action; it acts by coating the gastrointestinal tract to enhance imaging.
E-Z-HD is a barium sulfate contrast agent that acts by coating the mucosal surface of the gastrointestinal tract, providing radiographic contrast due to its high atomic number, which attenuates X-rays.
Oral: 1.5-3.0 mL/kg body weight (maximum 300 mL) of 1.5-2.0% barium sulfate suspension, administered as a single dose for upper GI studies; for CT colonography, 300-500 mL of 1.5-2.0% solution orally 12-24 hours prior to procedure.
Barium sulfate suspension, 60-120 mL (30-100% w/v) orally for single or double-contrast upper GI studies; for lower GI studies, 500-1500 mL (10-20% w/v) as enema.
None Documented
None Documented
Terminal elimination half-life: 1–2 hours; clinically, the short half-life allows rapid clearance of contrast agent.
Not applicable (non-absorbed, local GI agent; negligible systemic absorption)
Renal: approximately 100% excreted unchanged in urine within 24 hours; biliary/fecal: negligible (<1%).
Renal: 0%; Biliary/Fecal: 100% (eliminated unchanged in feces as insoluble barium sulfate)
Category C
Category C
Barium Sulfate Contrast Agent
Barium Sulfate Contrast Agent