Comparative Pharmacology
Head-to-head clinical analysis: FENOFIBRATE MICRONIZED versus FIBRICOR.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FENOFIBRATE MICRONIZED versus FIBRICOR.
FENOFIBRATE (MICRONIZED) vs FIBRICOR
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. It also increases apoproteins A-I and A-II, leading to increased HDL cholesterol.
FIBRICOR (fenofibrate) is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase, and reduces production of apolipoprotein C-III (an inhibitor of lipoprotein lipase). This leads to decreased triglyceride and increased HDL cholesterol levels.
Fenofibrate (micronized) 145 mg orally once daily; alternatively 48 mg orally once daily to 145 mg orally once daily as tolerated.
FIBRICOR (fenofibric acid) is dosed as 45 mg or 135 mg orally once daily, with or without food. The typical adult dose is 135 mg daily. For mixed dyslipidemia, the recommended dose is 135 mg once daily; for severe hypertriglyceridemia, start with 45 to 135 mg once daily, titrating based on response.
None Documented
None Documented
Terminal half-life of fenofibric acid is approximately 20 hours (range 19–27 hours) in adults, allowing once-daily dosing.
Terminal elimination half-life is approximately 20 hours (range 19-26 hours) in healthy volunteers, with clinical context indicating that steady state is achieved within 1 week of dosing.
Renal: 60% (as fenofibric acid and glucuronide conjugates); Fecal: 25%; Biliary: minor.
Approximately 60-70% of the dose is excreted renally as unchanged drug or glucuronide conjugate, and about 20-25% is excreted fecally. Biliary excretion is minimal.
Category A/B
Category C
Fibrate
Fibrate