Comparative Pharmacology
Head-to-head clinical analysis: FERRIC CITRATE versus LANTHANUM CARBONATE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FERRIC CITRATE versus LANTHANUM CARBONATE.
FERRIC CITRATE vs LANTHANUM CARBONATE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ferric citrate dissociates to provide ferric iron, which binds dietary phosphate in the gastrointestinal tract, forming insoluble ferric phosphate that is excreted in feces, thereby reducing serum phosphate levels. It also provides iron for erythropoiesis.
Lanthanum carbonate dissociates in the acidic gastric environment to release lanthanum ions, which bind to dietary phosphate in the gastrointestinal tract, forming insoluble lanthanum-phosphate complexes that are excreted in feces, reducing serum phosphate levels.
1-2 tablets (210-420 mg elemental iron) orally three times daily with meals.
Oral: 500-1000 mg three times daily with meals, titrated based on serum phosphate levels; maximum 3000 mg/day.
None Documented
None Documented
Clinical Note
moderateLanthanum carbonate + Gatifloxacin
"The serum concentration of Gatifloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Rosoxacin
"The serum concentration of Rosoxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Levofloxacin
"The serum concentration of Levofloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateApproximately 6 hours for absorbed iron; clinical effect on serum phosphate occurs within 1–2 weeks.
Terminal half-life not clinically defined due to minimal systemic absorption; effectively acts locally in GI tract.
Primarily fecal as unabsorbed iron (≥90%); minimal renal excretion (<1%) of absorbed iron.
Primarily fecal (>99%) as unabsorbed drug. Minimal renal elimination (<1%).
Category C
Category C
Phosphate Binder
Phosphate Binder
Lanthanum carbonate + Trovafloxacin
"The serum concentration of Trovafloxacin can be decreased when it is combined with Lanthanum carbonate."