Comparative Pharmacology
Head-to-head clinical analysis: FERRIC CITRATE versus PHOSLO.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FERRIC CITRATE versus PHOSLO.
FERRIC CITRATE vs PHOSLO
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ferric citrate dissociates to provide ferric iron, which binds dietary phosphate in the gastrointestinal tract, forming insoluble ferric phosphate that is excreted in feces, thereby reducing serum phosphate levels. It also provides iron for erythropoiesis.
Calcium acetate binds phosphate in the gastrointestinal tract, forming insoluble calcium phosphate that is excreted in feces, thereby reducing serum phosphate levels.
1-2 tablets (210-420 mg elemental iron) orally three times daily with meals.
667 mg (two 667-mg tablets or one 667-mg capsule) orally three times daily with meals, titrated to maintain serum phosphate between 3.5-5.5 mg/dL; maximum 4000 mg/day.
None Documented
None Documented
Approximately 6 hours for absorbed iron; clinical effect on serum phosphate occurs within 1–2 weeks.
Not applicable; minimal systemic absorption, local gastrointestinal action
Primarily fecal as unabsorbed iron (≥90%); minimal renal excretion (<1%) of absorbed iron.
Primarily fecal as unabsorbed drug; minimal renal elimination (<0.5%)
Category C
Category C
Phosphate Binder
Phosphate Binder