Comparative Pharmacology
Head-to-head clinical analysis: FLAGYL I V versus METRONIDAZOLE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FLAGYL I V versus METRONIDAZOLE.
FLAGYL I.V. vs METRONIDAZOLE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Metronidazole, a nitroimidazole antibiotic, is reduced by bacterial nitroreductases to form reactive intermediates that disrupt bacterial DNA and inhibit nucleic acid synthesis.
After entry into the cell, metronidazole is reduced by bacterial nitroreductases to form toxic metabolites that damage DNA and inhibit nucleic acid synthesis, leading to cell death.
500 mg IV every 6 hours. For severe infection, 750 mg IV every 6 hours.
500 mg intravenously every 8 hours or 500 mg orally every 8 hours; for bacterial vaginosis, 500 mg orally twice daily for 7 days; for trichomoniasis, 2 g orally as a single dose.
None Documented
None Documented
8 hours (range 6-12 hours) in adults; prolonged in hepatic impairment (up to 20 hours) and neonates.
Clinical Note
moderateMetronidazole + Sulfisoxazole
"The metabolism of Sulfisoxazole can be decreased when combined with Metronidazole."
Clinical Note
moderateMetronidazole + Cyclosporine
"The metabolism of Cyclosporine can be decreased when combined with Metronidazole."
Clinical Note
moderateMetronidazole + Fluconazole
"The metabolism of Fluconazole can be decreased when combined with Metronidazole."
Clinical Note
moderateMetronidazole + Clotrimazole
8 hours (range 6-10 hours) in adults; prolonged to 18-20 hours in severe hepatic impairment; requires adjustment in cirrhosis.
Renal (60-80% unchanged), fecal (6-15% as metabolites), biliary (minor).
Renal (60-80% unchanged drug), biliary/fecal (6-15% as metabolites, <20% unchanged).
Category C
Category A/B
Nitroimidazole Antibiotic
Nitroimidazole Antibiotic
"The metabolism of Clotrimazole can be decreased when combined with Metronidazole."