Comparative Pharmacology
Head-to-head clinical analysis: FLAGYL I V versus SOLOSEC.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FLAGYL I V versus SOLOSEC.
FLAGYL I.V. vs SOLOSEC
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Metronidazole, a nitroimidazole antibiotic, is reduced by bacterial nitroreductases to form reactive intermediates that disrupt bacterial DNA and inhibit nucleic acid synthesis.
Secnidazole is a nitroimidazole antibiotic that exerts its bactericidal activity by entering the bacterial cell and inhibiting DNA synthesis. The nitro group of secnidazole is reduced intracellularly to form free radicals and other reactive intermediates that damage bacterial DNA.
500 mg IV every 6 hours. For severe infection, 750 mg IV every 6 hours.
2 g orally as a single dose for trichomoniasis.
None Documented
None Documented
8 hours (range 6-12 hours) in adults; prolonged in hepatic impairment (up to 20 hours) and neonates.
Terminal elimination half-life approximately 8-12 hours in patients with normal renal function; may be prolonged in renal impairment
Renal (60-80% unchanged), fecal (6-15% as metabolites), biliary (minor).
Renal: approximately 75% as unchanged drug; fecal/biliary: minor (estimated <10%)
Category C
Category C
Nitroimidazole Antibiotic
Nitroimidazole Antibiotic