Comparative Pharmacology
Head-to-head clinical analysis: FLAXEDIL versus TRACRIUM PRESERVATIVE FREE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FLAXEDIL versus TRACRIUM PRESERVATIVE FREE.
FLAXEDIL vs TRACRIUM PRESERVATIVE FREE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
FLAXEDIL (gallamine triethiodide) is a nondepolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at nicotinic receptors at the neuromuscular junction, preventing muscle contraction.
Competitive antagonist of nicotinic acetylcholine receptors at the neuromuscular junction, blocking depolarization and preventing muscle contraction.
0.08-0.12 mg/kg IV bolus for neuromuscular blockade; additional doses of 0.01-0.02 mg/kg as needed.
Initial dose 0.4-0.5 mg/kg IV bolus for intubation; maintenance 0.08-0.1 mg/kg IV every 20-45 minutes as needed or continuous infusion 5-10 mcg/kg/min
None Documented
None Documented
The terminal elimination half-life of gallamine is approximately 2-4 hours in patients with normal renal function. This half-life is inversely related to creatinine clearance, and may be prolonged to 12-24 hours or more in patients with renal impairment, leading to cumulative effects and prolonged neuromuscular blockade.
Terminal elimination half-life: 20-30 minutes (healthy adults). Clinically, recovery is rapid due to redistribution and Hofmann elimination; prolonged in hypothermia or acidosis.
Flaxedil (gallamine triethiodide) is excreted primarily unchanged by the kidneys via glomerular filtration. Approximately 90-95% of an administered dose is eliminated in urine within 24 hours, with the remainder excreted in feces (<5%) via biliary elimination.
Renal: 10-20% unchanged; biliary/fecal: 50-60% as metabolites and parent drug; Hofmann elimination (non-enzymatic) accounts for ~45% of clearance.
Category C
Category C
Neuromuscular Blocking Agent
Neuromuscular Blocking Agent