Comparative Pharmacology
Head-to-head clinical analysis: FLOMAX versus SILODOSIN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FLOMAX versus SILODOSIN.
FLOMAX vs SILODOSIN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Selective antagonist of alpha-1A and alpha-1D adrenergic receptors in the prostate, bladder base, and bladder neck, leading to relaxation of smooth muscle and improved urinary flow.
Silodosin is a highly selective antagonist of alpha-1A adrenergic receptors located primarily in the prostate, bladder base, and proximal urethra. Blockade of these receptors relaxes smooth muscle in these tissues, reducing urinary outflow resistance and improving symptoms of benign prostatic hyperplasia (BPH). It has minimal affinity for alpha-1B receptors, thereby reducing the risk of orthostatic hypotension compared to non-selective alpha blockers.
0.4 mg orally once daily, approximately 30 minutes after the same meal each day. If no response after 2-4 weeks, may increase to 0.8 mg once daily.
8 mg orally once daily with a meal.
None Documented
None Documented
Clinical Note
moderateSilodosin + Digoxin
"The serum concentration of Digoxin can be increased when it is combined with Silodosin."
Clinical Note
moderateSilodosin + Levofloxacin
"The serum concentration of Levofloxacin can be increased when it is combined with Silodosin."
Clinical Note
moderateSilodosin + Tranilast
"Silodosin may increase the hypotensive activities of Tranilast."
Clinical Note
moderateSilodosin + Prednisone
Terminal elimination half-life is approximately 14-15 hours (range 6-20 hours) in healthy adults, allowing once-daily dosing.
Terminal half-life: 11-13 hours; allows once-daily dosing; prolongation in severe renal impairment
Primarily hepatic metabolism (CYP3A4, CYP2D6) with <10% excreted unchanged in urine; fecal excretion accounts for ~76% of metabolites.
Renal (33.5% as unchanged drug, 64.3% as metabolites); fecal (<5%)
Category C
Category A/B
Alpha-1 Blocker
Alpha-1 Blocker
"The serum concentration of Prednisone can be increased when it is combined with Silodosin."