Comparative Pharmacology
Head-to-head clinical analysis: FLOXIN OTIC versus PEDIOTIC.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FLOXIN OTIC versus PEDIOTIC.
FLOXIN OTIC vs PEDIOTIC
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Ofloxacin, a fluoroquinolone, inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
PEDIOTIC contains hydrocortisone, neomycin, and polymyxin B. Neomycin and polymyxin B are antibiotics that inhibit bacterial protein synthesis and disrupt bacterial cell membrane integrity, respectively. Hydrocortisone is a corticosteroid that suppresses inflammation by inhibiting phospholipase A2, reducing prostaglandin and leukotriene synthesis.
Instill 5 drops (0.5 mL) into affected ear(s) twice daily for 10-14 days; for acute otitis externa, may use 5 drops twice daily for 7 days.
Instill 4 drops into the affected ear(s) twice daily for 7-10 days.
None Documented
None Documented
6-8 hours in adults with normal renal function; prolonged to 30-50 hours in severe renal impairment (CrCl <20 mL/min).
Not established for topical otic use; systemic absorption is minimal. If absorbed, terminal half-life of dexamethasone is approximately 3-4 hours.
Primarily excreted unchanged in urine via glomerular filtration and tubular secretion (70-80%); non-renal elimination (hepatic metabolism and biliary secretion) accounts for 20-30%.
Renal elimination of absorbed drug (primarily unchanged) accounts for <10% of topically applied dose; fecal/biliary routes negligible.
Category C
Category C
Otic Antibiotic
Otic Antibiotic/Corticosteroid Combination