Comparative Pharmacology
Head-to-head clinical analysis: FLUOXETINE POSTPARTUM SAFETY versus LEXAPRO.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FLUOXETINE POSTPARTUM SAFETY versus LEXAPRO.
Fluoxetine-Safety-Postpartum vs LEXAPRO
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Selective serotonin reuptake inhibitor (SSRI); inhibits serotonin reuptake in the synaptic cleft, potentiating serotonergic activity in the CNS.
Selective serotonin reuptake inhibitor (SSRI); inhibits serotonin reuptake at the presynaptic neuron, potentiating serotonergic activity.
20 mg orally once daily, initially; may increase after several weeks to a maximum of 80 mg/day. Administer in the morning.
10 mg orally once daily; may increase to 20 mg once daily after at least 1 week.
None Documented
None Documented
Fluoxetine: 4-6 days (acute), 4-6 weeks (chronic); norfluoxetine: 4-16 days. Steady-state achieved after 2-4 weeks.
27-32 hours (mean ~30 h); steady state reached in ~1 week; linear kinetics at therapeutic doses.
Renal (80% as metabolites, 10% as unchanged drug) and fecal (15%)
Primarily renal (approx. 80% as metabolites, 8% as unchanged drug); biliary/fecal elimination accounts for ~15%.
Category A/B
Category C
SSRI Antidepressant
SSRI Antidepressant