Comparative Pharmacology
Head-to-head clinical analysis: FLUTEX versus HC 1.
Peer-Reviewed Evidence
Head-to-head clinical analysis: FLUTEX versus HC 1.
FLUTEX vs HC #1
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Flutamide is a nonsteroidal antiandrogen that competitively inhibits the binding of dihydrotestosterone (DHT) to androgen receptors in target tissues, thereby blocking the androgenic effects.
Unknown
50 mg orally once daily
Hydrocortisone: 100-200 mg IV as initial dose, then 50-100 mg IV every 6 hours, or 0.18 mg/kg/h IV continuous infusion.
None Documented
None Documented
Terminal elimination half-life: 24–36 hours, permitting once-daily dosing in chronic therapy
2–4 hours (terminal); prolonged in renal impairment.
Renal: ~70% (50% unchanged, 20% as metabolites); Biliary/fecal: ~30%
Renal: 90% as unchanged drug; fecal: 10%.
Category C
Category C
Topical Corticosteroid
Topical Corticosteroid