Comparative Pharmacology
Head-to-head clinical analysis: GO EVAC versus GOLYTELY.
Peer-Reviewed Evidence
Head-to-head clinical analysis: GO EVAC versus GOLYTELY.
GO-EVAC vs GOLYTELY
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Promotes gastrointestinal motility by acting as a stimulant laxative, likely through direct irritation of the colonic mucosa and possibly via local effects on enteric neurons.
Polyethylene glycol 3350 is an osmotic laxative that induces diarrhea by retaining water in the bowel lumen through osmotic activity. Electrolytes (sodium sulfate, potassium chloride, sodium bicarbonate) prevent significant electrolyte absorption or loss.
10 mg orally once daily, with or without food.
240 mL (oral) every 10 minutes until 4 L consumed or rectal effluent is clear; typically 4 L total over 3-4 hours.
None Documented
None Documented
4.5-6 hours in healthy volunteers; prolonged to 10-14 hours in elderly patients and those with moderate renal impairment (CrCl 30-50 mL/min).
Not applicable (PEG 3350 is not significantly absorbed; effective half-life in GI tract is approximately 2-4 hours for colonic clearance).
Primarily renal; approximately 60% eliminated unchanged in urine within 24 hours, with 20% as metabolites. Biliary/fecal excretion accounts for 15-20%, and the remainder is metabolized via glucuronidation.
Primarily fecal elimination of unabsorbed polyethylene glycol 3350. Minimal systemic absorption (<0.06%), less than 0.06% recovered in urine as intact PEG 3350; electrocytes and sulfate (from sodium sulfate) are renally excreted.
Category C
Category C
Osmotic Laxative
Osmotic Laxative