Comparative Pharmacology
Head-to-head clinical analysis: INDAPAMIDE versus LOZOL.
Peer-Reviewed Evidence
Head-to-head clinical analysis: INDAPAMIDE versus LOZOL.
INDAPAMIDE vs LOZOL
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Indapamide is a thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule by blocking the Na-Cl cotransporter, leading to increased excretion of sodium, chloride, and water. It also reduces peripheral vascular resistance through direct vasodilatory effects.
Thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, reducing plasma volume and extracellular fluid volume; also causes direct vasodilation through modulation of calcium channels.
1.25-2.5 mg orally once daily; 2.5 mg is usual maintenance dose; maximum 5 mg/day.
Indapamide: Oral, 1.25 mg once daily. May increase to 2.5 mg once daily if no response after 4 weeks.
None Documented
None Documented
Clinical Note
moderateIndapamide + Digoxin
"The risk or severity of adverse effects can be increased when Indapamide is combined with Digoxin."
Clinical Note
moderateIndapamide + Digitoxin
"The risk or severity of adverse effects can be increased when Indapamide is combined with Digitoxin."
Clinical Note
moderateIndapamide + Deslanoside
"The risk or severity of adverse effects can be increased when Indapamide is combined with Deslanoside."
Clinical Note
moderateIndapamide + Acetyldigitoxin
14–18 hours (terminal elimination half-life); prolonged in renal impairment, supporting once-daily dosing.
Terminal half-life: 14-18 hours (mean 16 hours); clinically significant for once-daily dosing
Renal excretion (70% unchanged, 23% as glucuronide conjugate); biliary/fecal elimination accounts for <5%.
Renal: 70% unchanged, Biliary/Fecal: 30% as metabolites
Category A/B
Category C
Thiazide-like Diuretic
Thiazide-like Diuretic
"The risk or severity of adverse effects can be increased when Indapamide is combined with Acetyldigitoxin."