Comparative Pharmacology
Head-to-head clinical analysis: ISMOTIC versus MANNITOL 25.
Peer-Reviewed Evidence
Head-to-head clinical analysis: ISMOTIC versus MANNITOL 25.
ISMOTIC vs MANNITOL 25%
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Isosmotic solution of mannitol; increases plasma osmolality, drawing water from tissues into the vasculature and reducing intracranial/intraocular pressure via osmotic diuresis.
Mannitol is an osmotic diuretic that increases plasma osmolarity, drawing water from intracellular and interstitial spaces into the intravascular compartment. In the kidney, it is filtered but not reabsorbed, increasing tubular fluid osmolarity and promoting water excretion. It also reduces intracranial and intraocular pressure by creating an osmotic gradient.
1-2 g orally every 6-8 hours, maximum 8 g/day; or 1-2 g intravenously over 5-10 minutes every 6-8 hours, maximum 8 g/day.
1-2 g/kg (4-8 mL/kg) intravenously as a 25% solution over 30-60 minutes; may repeat every 6-8 hours as needed.
None Documented
None Documented
4.5-6.0 hours in adults with normal renal function; prolonged in renal impairment (up to 24-48 hours in anuria)
Terminal elimination half-life: 0.25–1.7 hours; prolonged in renal impairment.
Renal: 90-95% unchanged; biliary/fecal: <5%
Renal: >90% unchanged by glomerular filtration; biliary/fecal: <5%.
Category C
Category A/B
Osmotic Diuretic
Osmotic Diuretic