Comparative Pharmacology
Head-to-head clinical analysis: LANTHANUM CARBONATE versus PHOSLO.
Peer-Reviewed Evidence
Head-to-head clinical analysis: LANTHANUM CARBONATE versus PHOSLO.
LANTHANUM CARBONATE vs PHOSLO
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Lanthanum carbonate dissociates in the acidic gastric environment to release lanthanum ions, which bind to dietary phosphate in the gastrointestinal tract, forming insoluble lanthanum-phosphate complexes that are excreted in feces, reducing serum phosphate levels.
Calcium acetate binds phosphate in the gastrointestinal tract, forming insoluble calcium phosphate that is excreted in feces, thereby reducing serum phosphate levels.
Oral: 500-1000 mg three times daily with meals, titrated based on serum phosphate levels; maximum 3000 mg/day.
667 mg (two 667-mg tablets or one 667-mg capsule) orally three times daily with meals, titrated to maintain serum phosphate between 3.5-5.5 mg/dL; maximum 4000 mg/day.
None Documented
None Documented
Clinical Note
moderateLanthanum carbonate + Gatifloxacin
"The serum concentration of Gatifloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Rosoxacin
"The serum concentration of Rosoxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Levofloxacin
"The serum concentration of Levofloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateTerminal half-life not clinically defined due to minimal systemic absorption; effectively acts locally in GI tract.
Not applicable; minimal systemic absorption, local gastrointestinal action
Primarily fecal (>99%) as unabsorbed drug. Minimal renal elimination (<1%).
Primarily fecal as unabsorbed drug; minimal renal elimination (<0.5%)
Category C
Category C
Phosphate Binder
Phosphate Binder
Lanthanum carbonate + Trovafloxacin
"The serum concentration of Trovafloxacin can be decreased when it is combined with Lanthanum carbonate."