Comparative Pharmacology
Head-to-head clinical analysis: LANTHANUM CARBONATE versus RENVELA.
Peer-Reviewed Evidence
Head-to-head clinical analysis: LANTHANUM CARBONATE versus RENVELA.
LANTHANUM CARBONATE vs RENVELA
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Lanthanum carbonate dissociates in the acidic gastric environment to release lanthanum ions, which bind to dietary phosphate in the gastrointestinal tract, forming insoluble lanthanum-phosphate complexes that are excreted in feces, reducing serum phosphate levels.
Renvela (sevelamer carbonate) is a phosphate-binding polymer that binds dietary phosphate in the gastrointestinal tract, inhibiting phosphate absorption and reducing serum phosphate levels. It also binds bile acids, leading to decreased LDL cholesterol.
Oral: 500-1000 mg three times daily with meals, titrated based on serum phosphate levels; maximum 3000 mg/day.
Adults: 800 mg orally three times daily with meals; titrate based on serum phosphorus levels up to 2400 mg per meal (7200 mg/day maximum).
None Documented
None Documented
Clinical Note
moderateLanthanum carbonate + Gatifloxacin
"The serum concentration of Gatifloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Rosoxacin
"The serum concentration of Rosoxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateLanthanum carbonate + Levofloxacin
"The serum concentration of Levofloxacin can be decreased when it is combined with Lanthanum carbonate."
Clinical Note
moderateTerminal half-life not clinically defined due to minimal systemic absorption; effectively acts locally in GI tract.
Not applicable as sevelamer is not absorbed. No systemic half-life; local gastrointestinal transit time is approximately 3-4 hours.
Primarily fecal (>99%) as unabsorbed drug. Minimal renal elimination (<1%).
Sevelamer carbonate is not absorbed systemically; excretion is entirely fecal as the parent compound. Less than 0.01% is absorbed and excreted renally.
Category C
Category C
Phosphate Binder
Phosphate Binder
Lanthanum carbonate + Trovafloxacin
"The serum concentration of Trovafloxacin can be decreased when it is combined with Lanthanum carbonate."