Comparative Pharmacology
Head-to-head clinical analysis: LEVAQUIN IN DEXTROSE 5 IN PLASTIC CONTAINER versus TROVAN PRESERVATIVE FREE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: LEVAQUIN IN DEXTROSE 5 IN PLASTIC CONTAINER versus TROVAN PRESERVATIVE FREE.
LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER vs TROVAN PRESERVATIVE FREE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Levofloxacin is a fluoroquinolone antibacterial that inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, thereby inhibiting DNA replication and transcription.
Inhibits DNA gyrase (topoisomerase II) and topoisomerase IV, thereby inhibiting bacterial DNA replication and transcription.
750 mg intravenously every 24 hours for 5 days. Alternatively, 500 mg intravenously every 24 hours for 7-14 days depending on infection.
200 mg intravenously once daily.
None Documented
None Documented
Terminal elimination half-life is approximately 6-8 hours in patients with normal renal function (creatinine clearance >80 mL/min); prolonged in renal impairment (up to 30-50 hours in severe impairment).
Terminal elimination half-life is approximately 10–13 hours in patients with normal renal function; prolonged in renal impairment.
Primarily renal excretion as unchanged drug (approximately 87% within 48 hours); less than 4% as metabolites; biliary/fecal excretion accounts for <5%.
Renal excretion accounts for approximately 90% of elimination, with ~50% as unchanged drug. Fecal/biliary excretion accounts for the remaining ~10%.
Category C
Category C
Antibiotic (Fluoroquinolone)
Antibiotic (Fluoroquinolone)