Comparative Pharmacology
Head-to-head clinical analysis: LUDIOMIL versus MIRTAZAPINE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: LUDIOMIL versus MIRTAZAPINE.
LUDIOMIL vs MIRTAZAPINE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Tricyclic antidepressant; inhibits reuptake of norepinephrine and serotonin at presynaptic terminals, increasing synaptic concentrations of these neurotransmitters.
Mirtazapine is a tetracyclic antidepressant that acts as an antagonist at presynaptic α2-adrenergic receptors, leading to increased norepinephrine and serotonin release. It also antagonizes 5-HT2 and 5-HT3 receptors, and histamine H1 receptors. It does not inhibit monoamine oxidase.
Oral, 75-150 mg daily in divided doses (or as a single dose at bedtime); may increase to 225 mg daily. Maximum: 300 mg daily.
Initial: 15 mg orally once daily at bedtime; titrate up to 45 mg/day as tolerated. Maintenance: 15-45 mg/day.
None Documented
None Documented
Clinical Note
moderateMirtazapine + Fluticasone propionate
"Mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Fluticasone propionate."
Clinical Note
moderateMirtazapine + Desmopressin
"The risk or severity of adverse effects can be increased when Mirtazapine is combined with Desmopressin."
Clinical Note
moderateMirtazapine + Haloperidol
"Mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Haloperidol."
Clinical Note
moderate51 hours (range 36–68 h) in adults; requires dose adjustment in hepatic impairment.
20-40 hours (mean 30 h); allows once-daily dosing; prolonged in elderly (up to 50 h) and hepatic impairment.
Primarily renal (≥60% as metabolites, ~2% unchanged); biliary/fecal excretion accounts for ~30%.
Renal (75% as metabolites, <4% unchanged) and fecal (25% via bile); total clearance 0.43 L/min.
Category C
Category A/B
Tetracyclic Antidepressant
Tetracyclic Antidepressant
Mirtazapine + Tenofovir disoproxil
"The metabolism of Tenofovir disoproxil can be decreased when combined with Mirtazapine."