Comparative Pharmacology
Head-to-head clinical analysis: LUVOX CR versus PROZAC.
Peer-Reviewed Evidence
Head-to-head clinical analysis: LUVOX CR versus PROZAC.
LUVOX CR vs PROZAC
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Selective serotonin reuptake inhibitor (SSRI); increases serotonin availability in the synaptic cleft by blocking serotonin reuptake transporters (SERT).
Selective serotonin reuptake inhibitor (SSRI); potentiates serotonergic activity in the CNS by blocking the reuptake of serotonin into presynaptic neurons.
100-300 mg orally once daily at bedtime
20 mg orally once daily, initially; may increase to 40 mg once daily after several weeks; maximum 80 mg once daily.
None Documented
None Documented
The terminal elimination half-life is approximately 15-20 hours after single doses and 17-26 hours after multiple doses. This supports once-daily dosing, with steady-state achieved within 1-2 weeks.
Fluoxetine: 4-6 days; norfluoxetine: 4-16 days; extensive accumulation with chronic dosing, steady-state in 4-5 weeks
Approximately 94% of a dose is excreted in urine, with less than 4% as unchanged drug. The remainder is eliminated in feces. Renal excretion of metabolites accounts for the majority of elimination.
Renal: ~80% (primarily as metabolites, <10% unchanged); fecal: ~15%
Category C
Category C
SSRI Antidepressant
SSRI Antidepressant