Comparative Pharmacology
Head-to-head clinical analysis: MALATHION versus OVIDE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: MALATHION versus OVIDE.
MALATHION vs OVIDE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Malathion is an organophosphate that irreversibly inhibits acetylcholinesterase, leading to accumulation of acetylcholine at cholinergic synapses, causing overstimulation of muscarinic and nicotinic receptors.
OVIDE (malathion) is an organophosphate insecticide that irreversibly inhibits acetylcholinesterase, leading to accumulation of acetylcholine at synapses, resulting in paralysis and death of lice. It also has pediculicidal and ovicidal activity.
0.5% lotion applied topically to entire body and left for 8-12 hours; repeat in 7-9 days if necessary.
Apply OVIDE (malathion 0.5% lotion) topically to dry hair and scalp, leave for 8-12 hours, then rinse thoroughly. Repeat in 7-9 days if live lice persist.
None Documented
None Documented
Clinical Note
moderateMalathion + Deferasirox
"The serum concentration of Deferasirox can be increased when it is combined with Malathion."
Clinical Note
moderateMalathion + Tenofovir disoproxil
"The metabolism of Tenofovir disoproxil can be decreased when combined with Malathion."
Clinical Note
moderateMalathion + Clotrimazole
"The metabolism of Clotrimazole can be decreased when combined with Malathion."
Clinical Note
moderateMalathion + Venlafaxine
Approximately 2-3 hours for malathion (parent compound). Metabolites (e.g., malaoxon) may persist longer. Clinically, elimination is rapid, limiting systemic toxicity with acute dermal exposure.
Terminal elimination half-life is approximately 8–10 hours in adults; prolonged in hepatic impairment.
Primarily renal excretion of water-soluble metabolites (e.g., malathion monocarboxylic acid, dicarboxylic acid). Less than 1% excreted unchanged in urine. Biliary/fecal excretion accounts for minor elimination of metabolites.
Primarily renal elimination of metabolites; <1% excreted unchanged in urine. Biliary/fecal excretion accounts for <5%.
Category C
Category C
Pediculicide
Pediculicide
"The metabolism of Venlafaxine can be decreased when combined with Malathion."