Comparative Pharmacology
Head-to-head clinical analysis: MANGANESE SULFATE versus MULTRYS.
Peer-Reviewed Evidence
Head-to-head clinical analysis: MANGANESE SULFATE versus MULTRYS.
MANGANESE SULFATE vs MULTRYS
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Manganese sulfate is a source of manganese, a trace element that acts as a cofactor for various enzymes including arginase, pyruvate carboxylase, and superoxide dismutase. It is essential for normal bone formation, blood clotting, and nervous system function.
MULTRYS is a multivitamin preparation for intravenous infusion; its components serve as coenzymes or cofactors in various metabolic pathways, including energy production, red blood cell formation, and antioxidant defense.
Intravenous: 0.1-0.2 mg manganese/kg/day (as manganese sulfate) added to TPN. Maximum 0.15-0.8 mg/day. Injection IV: 0.1-0.2 mg manganese/kg/day.
10 mL (one vial) intravenously three times per week, not to exceed 10 mL per dose.
None Documented
None Documented
Terminal elimination half-life approximately 37 days (range 30–45 days) in whole body; reflects slow turnover in tissues, especially bone and liver. Clinical context: Accumulation occurs with chronic high exposure or impaired biliary excretion (e.g., hepatic disease).
Not applicable as a single entity; values vary by component. For example: thiamine 10-20 minutes (plasma), riboflavin 1-2 hours, vitamin B6 2-3 weeks (tissue stores), vitamin C 16 days (10-20 days for depletion), biotin 1-2 days, folic acid 3-4 hours (plasma), vitamin B12 4-5 days (plasma), zinc 2-3 days (plasma), copper 12-24 hours, selenium 11-20 days, chromium 0.5-1 day, manganese 5-10 days.
Primarily fecal (biliary) elimination of unabsorbed manganese; absorbed manganese is excreted mainly in bile (99%) with minimal renal excretion (<1%). Small amounts secreted in pancreatic juice and reabsorbed enterally.
Renal elimination of individual vitamins and trace elements varies; no intact drug is excreted, as MULTRYS is a mixture. Approximate ranges: thiamine 50% unchanged in urine, riboflavin 60-70% as metabolites in urine, vitamin B6 70-80% as 4-pyridoxic acid in urine, vitamin C 50% unchanged in urine, biotin 50% unchanged in urine, folic acid mainly as metabolites in urine, vitamin B12 via bile (50-60%) and urine (10-30%). Trace elements: zinc primarily fecal (90%), copper primarily fecal (80-90%), selenium primarily urine (50-60%), chromium primarily urine (80%), manganese primarily fecal (95-97%).
Category C
Category C
Mineral Supplement
Multivitamin/Mineral Supplement