Comparative Pharmacology
Head-to-head clinical analysis: METHOXSALEN versus TRISORALEN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: METHOXSALEN versus TRISORALEN.
METHOXSALEN vs TRISORALEN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Methoxsalen is a psoralen that intercalates DNA, and upon UVA activation, forms covalent cross-links with pyrimidine bases, inhibiting DNA synthesis and cell division.
Psoralen (trisoralen) intercalates into DNA and, upon UVA irradiation, forms covalent cross-links between pyrimidine bases, inhibiting DNA replication and cell division. It also suppresses DNA synthesis and epidermal cell proliferation.
Oral: 0.4–0.6 mg/kg taken 1.5–2 hours before UVA exposure; typical dose range 10–70 mg. Topical: 0.1% lotion applied 1 hour before UVA.
10-70 mg orally 2 hours before UVA exposure, given 2-3 times per week, with dose based on body weight (0.6 mg/kg).
None Documented
None Documented
Clinical Note
moderateMethoxsalen + Verteporfin
"Methoxsalen may increase the photosensitizing activities of Verteporfin."
Clinical Note
moderateMethoxsalen + Artesunate
"The serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Methoxsalen resulting in a loss in efficacy."
Clinical Note
moderateMethoxsalen + Sulfisoxazole
"The metabolism of Sulfisoxazole can be decreased when combined with Methoxsalen."
Clinical Note
moderate2 hours (range 1-3 h); terminal half-life is 2 h after oral administration; no accumulation with once-daily dosing
Terminal elimination half-life is approximately 2 hours (range 1.1–2.5 h) for trioxsalen after oral administration; clinical phototoxic effect peaks at 2–4 hours post-dose.
Renal: 95% as metabolites (glucuronides); fecal: 4%; <0.1% unchanged in urine
Primarily renal elimination of metabolites; less than 5% excreted unchanged in urine. Approximately 90% of a radiolabeled dose is recovered in urine within 24 hours, with less than 5% in feces.
Category D/X
Category C
Psoralen
Psoralen
Methoxsalen + Erythromycin
"The metabolism of Erythromycin can be decreased when combined with Methoxsalen."