Comparative Pharmacology
Head-to-head clinical analysis: MIRALAX versus POLYETHYLENE GLYCOL 3350.
Peer-Reviewed Evidence
Head-to-head clinical analysis: MIRALAX versus POLYETHYLENE GLYCOL 3350.
MIRALAX vs POLYETHYLENE GLYCOL 3350
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Polyethylene glycol 3350 (PEG 3350) is an osmotic laxative that works by retaining water in the stool through hydrogen bonding, increasing fecal water content and promoting bowel movements.
Osmotic laxative. Polyethylene glycol 3350 is a non-absorbable polymer that retains water in the colon via hydrogen bonding, increasing stool water content and stimulating defecation.
17 g (1 heaping tablespoon) dissolved in 4–8 oz of water, juice, soda, coffee, or tea, administered orally once daily. Maximum duration of use: 7 days.
17 g (1 capful or packet) dissolved in 4–8 oz (120–240 mL) water, administered orally once daily for constipation; for colonoscopy preparation, 240 g (4 L of solution) ingested at 240 mL every 10–15 minutes.
None Documented
None Documented
Not applicable; polyethylene glycol 3350 is minimally absorbed and systemic half-life is not clinically relevant.
Terminal elimination half-life is 1-2 hours in patients with normal renal function; prolonged in renal impairment, but clinical impact minimal due to primarily fecal elimination.
Primarily excreted unchanged in feces (>90% of oral dose); negligible renal elimination (<0.1% recovered in urine).
Renal: approximately 20% excreted unchanged; Fecal: approximately 80% eliminated unchanged in feces.
Category C
Category C
Osmotic Laxative
Osmotic Laxative