Comparative Pharmacology
Head-to-head clinical analysis: MULTIHANCE versus OPTIMARK.
Peer-Reviewed Evidence
Head-to-head clinical analysis: MULTIHANCE versus OPTIMARK.
MULTIHANCE vs OPTIMARK
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Gadobenate dimeglumine is a paramagnetic contrast agent that increases signal intensity in magnetic resonance imaging (MRI) by shortening T1 relaxation times in tissues where it accumulates, primarily due its gadolinium content.
Gadolinium-based MRI contrast agent that increases signal intensity by shortening T1 relaxation time in tissues where it accumulates.
0.1 mmol/kg (0.2 mL/kg) IV as a single bolus injection; maximum dose 0.3 mmol/kg (0.6 mL/kg) for CNS imaging.
0.1 mmol/kg (0.2 mL/kg) intravenously as a single bolus injection; not to exceed 20 mL per dose.
None Documented
None Documented
Terminal elimination half-life: 2.0 hours in patients with normal renal function (creatinine clearance >60 mL/min); prolonged to up to 30 hours in end-stage renal disease
Terminal elimination half-life is approximately 1.5–2 hours in patients with normal renal function. In patients with severely impaired renal function (GFR <30 mL/min), half-life is significantly prolonged (up to 20 hours).
Renal: 95-100% (glomerular filtration) within 72 hours; fecal: <0.1%
Primarily renal excretion (glomerular filtration). >95% of the administered dose is eliminated unchanged in urine within 24 hours. Biliary/fecal elimination is negligible (<1%).
Category C
Category C
MRI Contrast Agent
MRI Contrast Agent