Comparative Pharmacology
Head-to-head clinical analysis: MULTIHANCE versus OPTIMARK IN PLASTIC CONTAINER.
Peer-Reviewed Evidence
Head-to-head clinical analysis: MULTIHANCE versus OPTIMARK IN PLASTIC CONTAINER.
MULTIHANCE vs OPTIMARK IN PLASTIC CONTAINER
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Gadobenate dimeglumine is a paramagnetic contrast agent that increases signal intensity in magnetic resonance imaging (MRI) by shortening T1 relaxation times in tissues where it accumulates, primarily due its gadolinium content.
Gadolinium-based paramagnetic contrast agent. The gadolinium ion (Gd3+) has seven unpaired electrons and a high magnetic moment, which enhances the relaxation rates of surrounding water protons in tissues, increasing signal intensity on T1-weighted magnetic resonance imaging (MRI) scans.
0.1 mmol/kg (0.2 mL/kg) IV as a single bolus injection; maximum dose 0.3 mmol/kg (0.6 mL/kg) for CNS imaging.
0.2 mL/kg (0.1 mmol/kg) IV bolus; may repeat once within 30 minutes for total dose of 0.4 mL/kg (0.2 mmol/kg) if needed for contrast-enhanced MRI.
None Documented
None Documented
Terminal elimination half-life: 2.0 hours in patients with normal renal function (creatinine clearance >60 mL/min); prolonged to up to 30 hours in end-stage renal disease
Terminal elimination half-life is approximately 2 hours in patients with normal renal function. In patients with severe renal impairment (GFR < 30 mL/min), half-life may be prolonged up to 30 hours.
Renal: 95-100% (glomerular filtration) within 72 hours; fecal: <0.1%
Primarily renal excretion via glomerular filtration; >90% of administered dose eliminated unchanged in urine within 24 hours. Less than 1% eliminated in feces.
Category C
Category C
MRI Contrast Agent
MRI Contrast Agent