Comparative Pharmacology
Head-to-head clinical analysis: MULTIHANCE versus TESLASCAN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: MULTIHANCE versus TESLASCAN.
MULTIHANCE vs TESLASCAN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Gadobenate dimeglumine is a paramagnetic contrast agent that increases signal intensity in magnetic resonance imaging (MRI) by shortening T1 relaxation times in tissues where it accumulates, primarily due its gadolinium content.
Teslascan is a manganese-based paramagnetic contrast agent that enhances T1-weighted magnetic resonance imaging (MRI). Manganese ions shorten the T1 relaxation time of protons, increasing signal intensity in tissues where it accumulates.
0.1 mmol/kg (0.2 mL/kg) IV as a single bolus injection; maximum dose 0.3 mmol/kg (0.6 mL/kg) for CNS imaging.
0.1 mL/kg (0.1 mmol/kg) intravenous bolus injection.
None Documented
None Documented
Terminal elimination half-life: 2.0 hours in patients with normal renal function (creatinine clearance >60 mL/min); prolonged to up to 30 hours in end-stage renal disease
Terminal elimination half-life is 6.2 hours in patients with normal renal function (CrCl > 60 mL/min). In patients with moderate renal impairment (CrCl 30-60 mL/min), half-life increases to 9.5 hours; in severe impairment (CrCl < 30 mL/min), half-life exceeds 15 hours.
Renal: 95-100% (glomerular filtration) within 72 hours; fecal: <0.1%
70% renal (unchanged drug), 30% fecal (biliary excretion).
Category C
Category C
MRI Contrast Agent
MRI Contrast Agent