Comparative Pharmacology
Head-to-head clinical analysis: OVIDE versus RID MOUSSE.
Peer-Reviewed Evidence
Head-to-head clinical analysis: OVIDE versus RID MOUSSE.
OVIDE vs RID MOUSSE
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
OVIDE (malathion) is an organophosphate insecticide that irreversibly inhibits acetylcholinesterase, leading to accumulation of acetylcholine at synapses, resulting in paralysis and death of lice. It also has pediculicidal and ovicidal activity.
RID Mousse contains pyrethrins and piperonyl butoxide. Pyrethrins act on the nervous system of lice by disrupting sodium channels, causing paralysis and death. Piperonyl butoxide inhibits insect cytochrome P450 microsomal enzymes, enhancing the activity of pyrethrins.
Apply OVIDE (malathion 0.5% lotion) topically to dry hair and scalp, leave for 8-12 hours, then rinse thoroughly. Repeat in 7-9 days if live lice persist.
Topical: Apply twice daily (morning and evening) to affected areas of the scalp and/or skin. Use enough to cover the area, typically 1–2 mL per application. Rinse after 1–3 minutes.
None Documented
None Documented
Terminal elimination half-life is approximately 8–10 hours in adults; prolonged in hepatic impairment.
Terminal elimination half-life is 24 hours (range 20-30 hours); clinically, steady-state is reached after 5-7 days.
Primarily renal elimination of metabolites; <1% excreted unchanged in urine. Biliary/fecal excretion accounts for <5%.
Renal excretion of unchanged drug accounts for approximately 60% of elimination; fecal/biliary elimination accounts for 25%; 15% metabolized with metabolites excreted renally.
Category C
Category C
Pediculicide
Pediculicide