Comparative Pharmacology
Head-to-head clinical analysis: PENICILLIN versus UNIPEN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: PENICILLIN versus UNIPEN.
PENICILLIN vs UNIPEN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation and autolysin activation, leading to cell lysis.
Unipen (nafcillin) is a penicillinase-resistant penicillin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), blocking transpeptidation and autolysin inhibition.
Penicillin G: 2-4 million units IV every 4-6 hours; Penicillin V: 250-500 mg orally every 6 hours for mild to moderate infections.
500 mg to 2 g orally or intravenously every 4 to 6 hours; maximum 12 g/day IV for serious infections.
None Documented
None Documented
0.5-1.0 hours in normal renal function; prolonged to 7-10 hours in anuria. Dose adjustment required in renal impairment.
Clinical Note
moderateBenzylpenicillin + Teriflunomide
"The serum concentration of Teriflunomide can be increased when it is combined with Benzylpenicillin."
Clinical Note
moderateBenzylpenicillin + Acemetacin
"Benzylpenicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderateProcaine benzylpenicillin + Acemetacin
"Procaine benzylpenicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."
Clinical Note
moderate0.5-1 hour in normal renal function; prolonged to 7-10 hours in anuria or severe renal impairment.
Primarily renal (60-80% unchanged via glomerular filtration and tubular secretion); biliary/fecal excretion accounts for 10-20%.
Renal: 70-90% unchanged via tubular secretion and glomerular filtration; biliary: minor (<10%); fecal: minimal.
Category C
Category C
Penicillin Antibiotic
Penicillin Antibiotic
Phenoxymethylpenicillin + Acemetacin
"Phenoxymethylpenicillin may decrease the excretion rate of Acemetacin which could result in a higher serum level."