Comparative Pharmacology
Head-to-head clinical analysis: PRAZIQUANTEL versus VERMOX.
Peer-Reviewed Evidence
Head-to-head clinical analysis: PRAZIQUANTEL versus VERMOX.
PRAZIQUANTEL vs VERMOX
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Praziquantel increases the permeability of schistosome cell membranes to calcium ions, causing severe contraction and paralysis of the worm musculature, leading to dislodgment and death.
Binds to β-tubulin in parasitic cells, inhibiting microtubule polymerization, thereby impairing glucose uptake and causing energy depletion and parasite death.
20 mg/kg orally three times daily for 1 day for schistosomiasis; 25 mg/kg orally three times daily for 1 day for clonorchiasis and opisthorchiasis; 5-10 mg/kg orally single dose for taeniasis; 15-25 mg/kg orally single dose for hymenolepiasis; 25 mg/kg orally three times daily for 1 day for paragonimiasis, fasciolopsiasis, and heterophyiasis.
Mebendazole 100 mg orally twice daily for 3 days for pinworm, whipworm, hookworm, and roundworm infections. For pinworm, may repeat after 2 weeks. For hookworm and whipworm, may require longer courses.
None Documented
None Documented
Clinical Note
moderatePraziquantel + Tenofovir disoproxil
"The metabolism of Tenofovir disoproxil can be decreased when combined with Praziquantel."
Clinical Note
moderatePraziquantel + Sulfisoxazole
"The metabolism of Sulfisoxazole can be decreased when combined with Praziquantel."
Clinical Note
moderatePraziquantel + Erythromycin
"The metabolism of Erythromycin can be decreased when combined with Praziquantel."
Clinical Note
moderatePraziquantel + Cyclosporine
Terminal elimination half-life is 1-1.5 hours for praziquantel; 4-6 hours for its main metabolite (4-hydroxypraziquantel). Half-life prolonged in patients with severe hepatic impairment.
2-8 hours (terminal half-life, may be prolonged in hepatic impairment or obstruction)
Primarily renal: approximately 80% of metabolites excreted in urine (unchanged drug <0.1%); fecal excretion accounts for about 15%.
Fecal (90%) as unchanged drug and metabolites; renal (<10%)
Category A/B
Category C
Anthelmintic
Anthelmintic
"The metabolism of Cyclosporine can be decreased when combined with Praziquantel."