Comparative Pharmacology
Head-to-head clinical analysis: PROZAC versus PROZAC WEEKLY.
Peer-Reviewed Evidence
Head-to-head clinical analysis: PROZAC versus PROZAC WEEKLY.
PROZAC vs PROZAC WEEKLY
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Selective serotonin reuptake inhibitor (SSRI); potentiates serotonergic activity in the CNS by blocking the reuptake of serotonin into presynaptic neurons.
Selective serotonin reuptake inhibitor (SSRI); potentiates serotonergic activity by blocking reuptake of serotonin at the presynaptic neuronal membrane.
20 mg orally once daily, initially; may increase to 40 mg once daily after several weeks; maximum 80 mg once daily.
90 mg orally once weekly
None Documented
None Documented
Fluoxetine: 4-6 days; norfluoxetine: 4-16 days; extensive accumulation with chronic dosing, steady-state in 4-5 weeks
Fluoxetine: 4-6 days after single dose, 4-6 days (extended to 7-9 days with chronic dosing due to autoinhibition of CYP2D6); norfluoxetine: 9-31 days. Steady state achieved after 2-4 weeks.
Renal: ~80% (primarily as metabolites, <10% unchanged); fecal: ~15%
Renal excretion of metabolites (primarily fluoxetine glucuronide and norfluoxetine glucuronide) accounts for approximately 80% of elimination; fecal excretion accounts for approximately 15%.
Category C
Category C
SSRI Antidepressant
SSRI Antidepressant