Comparative Pharmacology
Head-to-head clinical analysis: TENORETIC 50 versus TENORMIN.
Peer-Reviewed Evidence
Head-to-head clinical analysis: TENORETIC 50 versus TENORMIN.
TENORETIC 50 vs TENORMIN
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Atenolol is a cardioselective beta-1 adrenergic receptor antagonist that reduces heart rate, myocardial contractility, and blood pressure. Chlorthalidone is a thiazide-like diuretic that inhibits sodium-chloride symporter in the distal convoluted tubule, increasing excretion of sodium and water, reducing plasma volume.
Selective beta-1 adrenergic receptor antagonist; blocks catecholamine effects at beta-1 receptors, reducing heart rate, myocardial contractility, and blood pressure.
1 tablet (atenolol 50 mg / chlorthalidone 25 mg) orally once daily, may increase to 2 tablets once daily if needed.
Hypertension: 50 mg orally once daily; may increase to 100 mg once daily. Angina: 50 mg orally once daily; may increase to 100 mg once daily. Acute MI: 5 mg IV over 5 minutes, followed by 50 mg orally 15 minutes later, then 50 mg orally 12 hours later, then 100 mg orally once daily.
None Documented
None Documented
Atenolol: 6-7 hr (up to 20 hr in renal impairment); chlorthalidone: 40-60 hr (prolonged in renal impairment)
6-7 hours (terminal); prolonged to 16-27 hours in renal impairment (CrCl <35 mL/min).
Renal: atenolol 40-50% unchanged, chlorthalidone >95% unchanged; biliary/fecal minimal
Renal elimination of unchanged drug (40-50%) and hepatic metabolism to inactive metabolites excreted in urine; <5% fecal.
Category C
Category C
Beta blocker/thiazide diuretic combination
Beta blocker