Comparative Pharmacology
Head-to-head clinical analysis: VANCOMYCIN versus VANCOR.
Peer-Reviewed Evidence
Head-to-head clinical analysis: VANCOMYCIN versus VANCOR.
VANCOMYCIN vs VANCOR
Comparing the clinical profiles, pharmacokinetic behaviors, and safety indices of these two therapeutic agents.
Inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of the peptidoglycan precursor, blocking polymerization and cross-linking.
Inhibits cell wall synthesis by binding to the D-alanyl-D-alanine terminus of peptidoglycan precursors, blocking transglycosylation and transpeptidation.
15-20 mg/kg IV every 8-12 hours (maximum single dose 2 g, maximum daily dose 4 g) with target trough concentrations of 15-20 mg/L for serious infections.
Vancomycin 15-20 mg/kg IV every 8-12 hours, with target trough 10-20 mcg/mL; for serious infections, consider loading dose 25-30 mg/kg IV.
None Documented
None Documented
Terminal elimination half-life is approximately 4-6 hours in adults with normal renal function (creatinine clearance >90 mL/min). In severe renal impairment (CrCl <30 mL/min), half-life may extend to 24-48 hours or longer, necessitating therapeutic drug monitoring.
Clinical Note
moderateVancomycin + Benzydamine
"The serum concentration of Benzydamine can be increased when it is combined with Vancomycin."
Clinical Note
moderateVancomycin + Droxicam
"The serum concentration of Droxicam can be increased when it is combined with Vancomycin."
Clinical Note
moderateVancomycin + Loxoprofen
"The serum concentration of Loxoprofen can be increased when it is combined with Vancomycin."
Clinical Note
moderateVancomycin + Clonixin
Terminal elimination half-life is 4-6 hours in adults with normal renal function; can extend to 7-9 days in anuric patients, necessitating therapeutic drug monitoring.
Vancomycin is primarily excreted unchanged via glomerular filtration, with over 90% of a dose recovered in urine within 24 hours. Minor biliary/fecal elimination accounts for <5%.
Renal excretion of unchanged drug accounts for 80-90% of clearance via glomerular filtration; minor biliary excretion (<5%) and fecal elimination (<5%).
Category A/B
Category C
Glycopeptide Antibiotic
Glycopeptide Antibiotic
"The serum concentration of Clonixin can be increased when it is combined with Vancomycin."