DEXTROSE 5% IN RINGER'S IN PLASTIC CONTAINER
Clinical safety rating: caution
Comprehensive clinical and safety monograph for DEXTROSE 5% IN RINGER'S IN PLASTIC CONTAINER (DEXTROSE 5% IN RINGER'S IN PLASTIC CONTAINER).
Dextrose is a monosaccharide that serves as a source of calories and water for hydration. It is metabolized to carbon dioxide and water, yielding energy. Ringer's solution provides electrolytes (sodium, chloride, potassium, calcium) to maintain fluid and electrolyte balance.
| Metabolism | Dextrose is metabolized via glycolysis and the citric acid cycle to carbon dioxide and water, yielding energy. Metabolism is insulin-dependent; in the presence of insulin, it is taken up by cells and phosphorylated to glucose-6-phosphate. |
| Excretion | Renal: dextrose is completely metabolized; no significant renal excretion of intact dextrose. Ringer's solution components (Na+, K+, Ca2+, Cl-) are primarily excreted renally, with >90% of infused ions eliminated unchanged in urine. |
| Half-life | Dextrose: not applicable as it is rapidly metabolized; exogenous dextrose has an elimination half-life of approximately 0.5-1 hour due to insulin-mediated uptake and metabolism. Electrolytes: no relevant half-life. |
| Protein binding | Dextrose: negligible (<5%, not bound to proteins). Electrolytes: minimal protein binding (Na+, K+, Ca2+: <10% bound primarily to albumin for calcium). |
| Volume of Distribution | Dextrose: ~0.5 L/kg (total body water). Electrolytes: distribute into extracellular fluid (~0.2 L/kg). |
| Bioavailability | Intravenous: 100%. |
| Onset of Action | Intravenous: immediate (seconds to minutes) for volume expansion and correction of electrolyte imbalances; dextrose metabolism begins within minutes. |
| Duration of Action | Intravenous: effects on volume status last 1-2 hours depending on infusion rate; dextrose effect persists as long as infusion continues; electrolyte effects persist for duration of infusion plus renal excretion time. |
Intravenous infusion; dosing based on glucose requirements and fluid status. Typical adult dose: 500-1000 mL at 1-2 mL/min. Not to exceed 0.5 g/kg/h glucose.
| Dosage form | INJECTABLE |
| Renal impairment | No specific dose adjustment. Use with caution in renal impairment due to potential fluid overload; monitor electrolytes and glucose. |
| Liver impairment | No specific dose adjustment. Monitor glucose closely in severe hepatic impairment due to altered gluconeogenesis. |
| Pediatric use | Intravenous infusion; initial rate 5-10 mL/kg, then titrate. Maximum glucose infusion rate: 0.2-0.3 g/kg/h for term infants. |
| Geriatric use | Use lower initial infusion rates (0.5-1 mL/min) and monitor for fluid overload and hyperglycemia due to decreased renal function and glucose tolerance. |
| 1st trimester | Consult provider |
| 2nd trimester | Consult provider |
| 3rd trimester | Consult provider |
Clinical note
Comprehensive clinical and safety monograph for DEXTROSE 5% IN RINGER'S IN PLASTIC CONTAINER (DEXTROSE 5% IN RINGER'S IN PLASTIC CONTAINER).
| Breastfeeding | Dextrose and electrolytes are normal components of breast milk. IV infusion does not pose risk to nursing infant. M/P ratio not applicable as dextrose is endogenous. |
| Teratogenic Risk | Dextrose 5% in Ringer's solution is not teratogenic. Dextrose is a physiologic sugar; Ringer's solution contains electrolytes at concentrations similar to plasma. No fetal risks are reported from IV administration at standard doses. Excessive dextrose may cause maternal hyperglycemia, which can lead to fetal macrosomia and neonatal hypoglycemia, but this is not teratogenic. |
■ FDA Black Box Warning
None
| Serious Effects |
["Hypersensitivity to any component","Hyperglycemia with severe dehydration","Intracranial hemorrhage","Hepatic coma","Severe renal impairment with oliguria or anuria"]
| Precautions | ["Use with caution in patients with hyperglycemia, diabetes mellitus, or glucose intolerance","Monitor serum electrolytes, fluid balance, and blood glucose levels","Risk of fluid overload in patients with cardiac or renal impairment","May cause hyperglycemia, hyperosmolality, and osmotic diuresis","Not for use in patients with intracranial hemorrhage or hepatic coma"] |
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| Fetal Monitoring | Monitor maternal blood glucose levels, especially in gestational diabetes. Assess fluid balance for signs of overload (edema, pulmonary congestion). In prolonged infusion, monitor serum electrolytes. |
| Fertility Effects | No known effects on fertility. Dextrose and Ringer's solution are physiologic and do not impair reproductive function. |