Positive evidence of fetus risks but benefits may outweigh risks in some cases
How it works
Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.
Dosing & administration
Dosing varies by indication and patient profile. Always follow your institution's current prescribing guidelines.
Renal impairment
Consult protocols for adjustment.
Liver impairment
Consult protocols for adjustment.
Use during pregnancy
1st trimester
Not indicated.
2nd trimester
Not indicated.
3rd trimester
Safe for cervical ripening in eligible patients. Contraindicated with prior classical uterine incision, active herpes, or non-reassuring fetal status.
Clinical note
Prostaglandin E2 used for cervical ripening prior to labor induction (intracervical gel or vaginal insert/Cervidil). Effective and safe for this indication in the third trimester. Must not be used in women with prior uterine surgery (classical cesarean scar) due to uterine rupture risk. Remove vaginal insert before initiating oxytocin. Prostaglandins are contraindicated as tocolytics (opposite mechanism).
Breastfeeding
Not applicable. Short-course intrapartum use only.
