Positive evidence of fetus risks but benefits may outweigh risks in some cases
How it works
Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.
Dosing & administration
Dosing varies by indication and patient profile. Always follow your institution's current prescribing guidelines.
Renal impairment
Consult protocols for adjustment.
Liver impairment
Consult protocols for adjustment.
Use during pregnancy
1st trimester
Use with caution and only if benefits outweigh risks. Some data suggest modest increase in miscarriage risk.
2nd trimester
Avoid from 20 weeks onward. Risk of oligohydramnios and fetal renal injury; if used before 20 weeks limit duration.
3rd trimester
Strictly avoid. Can cause premature ductal closure, fetal pulmonary hypertension, and neonatal renal failure.
Clinical note
Avoid, especially after 20 weeks gestation. Associated with premature closure of the ductus arteriosus and fetal renal dysfunction leading to oligohydramnios. The FDA strengthened its warning in 2020 to include all NSAIDs from 20 weeks onward. Some studies suggest a modest increase in early miscarriage risk with first-trimester use, though evidence is not definitive.
Breastfeeding
Safe during breastfeeding. Minimal excretion into breast milk; ibuprofen is the preferred NSAID for postpartum pain due to its short half-life.
