INFUVITE ADULT
Clinical safety rating: caution
Comprehensive clinical and safety monograph for INFUVITE ADULT (INFUVITE ADULT).
Infuvite Adult is a multivitamin preparation that provides essential vitamins and minerals to supplement dietary intake. The specific mechanism varies by component; for example, B vitamins act as coenzymes in metabolic processes, vitamin C is an antioxidant and cofactor for hydroxylation reactions, and vitamin D regulates calcium homeostasis.
| Metabolism | Vitamins are metabolized via various pathways: B vitamins are phosphorylated and converted to active coenzymes; vitamin C is oxidized to dehydroascorbic acid; vitamin D is hydroxylated in liver and kidney; vitamin A is metabolized to retinoic acid; vitamin E is metabolized via CYP enzymes; vitamin K is partially metabolized in liver. |
| Excretion | Vitamins are primarily metabolized in the liver; renal excretion of metabolites; minimal biliary/fecal elimination (<10% unchanged). |
| Half-life | Variable; water-soluble vitamins (e.g., B1, B2, B6, C): 2-24 hours; fat-soluble vitamins (e.g., A, D, E, K): weeks to months. Clinical context: daily dosing needed for water-soluble; fat-soluble vitamins accumulate. |
| Protein binding | Variable: vitamin A (retinol) ~90% bound to retinol-binding protein; vitamin D 85-90% to vitamin D-binding protein; vitamin E ~90% to lipoproteins; others (B-complex, C) <10% bound. |
| Volume of Distribution | Not well-defined; water-soluble vitamins distribute into total body water (~0.55 L/kg); fat-soluble vitamins distribute into adipose tissue and liver (10-40 L). Clinical meaning: large Vd for fat-soluble vitamins indicates extensive tissue storage. |
| Bioavailability | Intravenous: 100%; intramuscular: near-complete absorption; oral: not applicable (IV formulation). For comparison, oral multivitamins: water-soluble ~50-90%, fat-soluble 20-60% depending on formulation. |
| Onset of Action | Intravenous: immediate (within minutes) for metabolic effects; intramuscular: 15-30 minutes for systemic action. |
| Duration of Action | Water-soluble vitamins: 24-48 hours; fat-soluble vitamins: weeks to months. Clinical note: repeat IV doses recommended weekly for TPN patients. |
10 mL (one vial) added to 500 mL or 1 L of compatible intravenous fluid, infused intravenously over 8-24 hours, once daily.
| Dosage form | SOLUTION |
| Renal impairment | No dose adjustment required for GFR < 60 mL/min/1.73 m2. For patients on dialysis, monitor for accumulation of vitamins A and K; consider reducing dose to 5 mL daily if prolonged therapy. |
| Liver impairment | For Child-Pugh Class A: no adjustment. For Child-Pugh Class B or C: use with caution; consider reducing to 5 mL daily due to risk of vitamin A and D toxicity, and monitor serum levels. |
| Pediatric use | Infants ≤ 2.5 kg: 0.5 mL/kg/day. Infants > 2.5 kg and children ≤ 11 years: 2.5 mL/day. Children ≥ 11 years: same as adult (10 mL/day). Administer in compatible IV fluid over 8-24 hours. |
| Geriatric use | No specific dose adjustment; use standard adult dosing (10 mL/day). Monitor for signs of vitamin A and D toxicity in patients with impaired renal or hepatic function, as elderly patients may have reduced clearance. |
| 1st trimester | Consult provider |
| 2nd trimester | Consult provider |
| 3rd trimester | Consult provider |
Clinical note
Comprehensive clinical and safety monograph for INFUVITE ADULT (INFUVITE ADULT).
| Breastfeeding | Vitamins in Infuvite Adult are excreted into breast milk in small amounts consistent with maternal nutritional status. No specific M/P ratio is available. Avoid excessive doses of vitamin A (retinol) and vitamin D, as high levels can be harmful to the infant. At recommended doses, the product is considered compatible with breastfeeding. |
| Teratogenic Risk | Infuvite Adult is a multivitamin formulation for intravenous use. Doses within the recommended Dietary Reference Intake (DRI) are generally considered safe in pregnancy. However, high doses of vitamin A (retinol) are teratogenic (associated with central nervous system, cardiovascular, and craniofacial defects) in the first trimester. Vitamin D excess may cause hypercalcemia and fetal anomalies. The product contains vitamin A 3300 IU and vitamin D 200 IU, which are within safe limits. No known teratogenicity from other components at standard doses. |
■ FDA Black Box Warning
None
| Serious Effects |
["Hypersensitivity to any component","Pre-existing hypervitaminosis"]
| Precautions | ["Allergic reactions including anaphylaxis","Aluminum toxicity in patients with renal impairment","Ensure solution compatibility","Not for direct intravenous injection"] |
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| Fetal Monitoring | Monitor maternal serum levels of vitamin A and vitamin D if prolonged high-dose therapy is used. Assess for signs of hypervitaminosis (e.g., hypercalcemia, hepatotoxicity). Fetal monitoring includes ultrasound for anomalies if high-dose vitamin A exposure occurs in first trimester. No routine monitoring required for standard doses. |
| Fertility Effects | No known adverse effects on fertility at recommended doses. Vitamin A excess may impair fertility in animal studies; not documented at standard human doses. |