INFUVITE PEDIATRIC
Clinical safety rating: caution
Comprehensive clinical and safety monograph for INFUVITE PEDIATRIC (INFUVITE PEDIATRIC).
INFUVITE PEDIATRIC is a multivitamin preparation that provides essential vitamins (A, B complex, C, D, E, K, and folic acid) that act as cofactors and coenzymes in various metabolic pathways, including energy production, protein and nucleic acid synthesis, and antioxidant defense.
| Metabolism | Vitamins in INFUVITE PEDIATRIC are metabolized via hepatic and extrahepatic pathways; specific enzymes include alcohol dehydrogenase (vitamin A), cytochrome P450 (vitamin D), and various tissue-specific enzymes for B vitamins and vitamin C. |
| Excretion | Excretion of vitamins in Infuvite Pediatric is primarily renal for water-soluble vitamins (B-complex and C), with negligible biliary/fecal elimination. Fat-soluble vitamins (A, D, E, K) are not readily excreted; small amounts may appear in bile/faeces. Specific %: not available due to extensive metabolism and tissue storage. |
| Half-life | Terminal half-life varies by vitamin: thiamine ~20-30 min; riboflavin ~1.3 h; pyridoxine ~2-3 h; ascorbic acid ~16 d; retinol (vitamin A) ~6-18 h; ergocalciferol (D2) ~2-3 d; alpha-tocopherol (E) ~12 h; phytonadione (K1) ~6-8 h. Clinical context: rapid clearance of water-soluble vitamins necessitates daily dosing; fat-soluble vitamins accumulate with repeated dosing. |
| Protein binding | Binding varies: vitamin A (retinol) ~90% bound to retinol-binding protein and albumin; vitamin D ~85% to vitamin D-binding protein (DBP); vitamin E ~90% bound to lipoproteins; vitamin K ~80% bound to lipoproteins; water-soluble vitamins minimal binding (<10% for most). |
| Volume of Distribution | Extensive distribution for water-soluble vitamins: ascorbic acid Vd ~0.3-0.6 L/kg; thiamine ~0.3 L/kg; riboflavin ~0.5 L/kg; pyridoxine ~0.6 L/kg. Fat-soluble vitamins have large Vd (vitamin A ~0.7 L/kg; vitamin D ~0.5-1 L/kg; vitamin E ~2-4 L/kg; vitamin K ~0.3 L/kg) indicating tissue storage. |
| Bioavailability | Intravenous route yields 100% bioavailability. Infuvite Pediatric is for IV administration only; not given orally. Bioavailability of oral components is variable (e.g., thiamine ~5-10%; riboflavin ~60%; pyridoxine ~75%; ascorbic acid ~70-90%; fat-soluble vitamins 30-70%) but not relevant for this product. |
| Onset of Action | Intravenous administration: clinical effects (e.g., correction of deficiency symptoms) typically within hours to days depending on vitamin. For beriberi (thiamine): improvement in heart failure symptoms within 6-12 h. |
| Duration of Action | Duration of clinical effect: water-soluble vitamins have short duration requiring daily supplementation; fat-soluble vitamins have longer duration (weeks to months) due to tissue storage. In acute deficiency, effect of single dose may last days. |
INFUVITE PEDIATRIC is not indicated for adult use; adult multivitamin formulations are recommended.
| Dosage form | INJECTABLE |
| Renal impairment | No specific dose adjustment guidelines; use with caution in severe renal impairment due to potential accumulation of vitamin A and water-soluble vitamins. |
| Liver impairment | No specific dose adjustment guidelines; contraindicated in severe hepatic dysfunction (Child-Pugh class C) due to risk of vitamin A toxicity and impaired metabolism. |
| Pediatric use | Infants and children ≤11 years: 1 vial (5 mL) added to intravenous fluids, administered over 1-2 hours, once daily. Dose based on age and weight; for preterm infants, consider reduced volume due to multivitamin sensitivity. |
| Geriatric use | Not indicated for geriatric use; adult formulations are recommended. If used, monitor for toxicity due to potential reduced renal function and hepatic clearance. |
| 1st trimester | Consult provider |
| 2nd trimester | Consult provider |
| 3rd trimester | Consult provider |
Clinical note
Comprehensive clinical and safety monograph for INFUVITE PEDIATRIC (INFUVITE PEDIATRIC).
| Breastfeeding | Excretion into breast milk is likely for water-soluble vitamins; fat-soluble vitamins may accumulate. M/P ratio not reported. Generally considered compatible with breastfeeding at recommended doses. |
| Teratogenic Risk | INFUVITE PEDIATRIC contains vitamins and minerals at physiological levels. No teratogenic risk at recommended doses; however, vitamin A in excess of 10,000 IU/day (as retinyl palmitate) is teratogenic. INFUVITE PEDIATRIC provides 2300 IU vitamin A, which is below the teratogenic threshold. First trimester: no increased risk. Second/third trimester: no fetal harm at recommended doses. |
■ FDA Black Box Warning
None.
| Serious Effects |
["Absolute: known hypersensitivity to any component.","Relative: hypervitaminosis (e.g., hypercalcemia from vitamin D), severe hepatic or renal impairment (for certain vitamins)."]
| Precautions | ["Allergic reactions have been reported, especially in patients with sensitivity to thiamine, vitamin B12, or folic acid.","Rare but serious: hypervitaminosis with excessive dosing, particularly vitamins A, D, E, K.","Use with caution in patients with malabsorption syndromes or electrolyte imbalances.","Contains aluminum; may be toxic with prolonged use in renal impairment."] |
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| Fetal Monitoring | Monitor for signs of vitamin toxicity (e.g., hypervitaminosis A) with prolonged use. No specific fetal monitoring required. |
| Fertility Effects | No adverse effects on fertility at recommended doses. |