Gold standard for managing diabetes in pregnancy (Type 1, Type 2, and GDM). Does not cross the placenta. Provides precise titration with no teratogenic potential. Insulin analogs (aspart, lispro, detemir) have been shown safe in pregnancy. Glargine has less data but is used in practice. The only antidiabetic that does not cross the placenta.
How it works
Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.
Dosing & administration
Dosing varies by indication and patient profile. Always follow your institution's current prescribing guidelines.
Renal impairment
Consult protocols for adjustment.
Liver impairment
Consult protocols for adjustment.
Use during pregnancy
1st trimester
Safe and essential. Tight glycemic control in T1 prevents congenital malformations from hyperglycemia-induced oxidative stress.
2nd trimester
Safe. Insulin requirements typically increase due to placental hormones causing insulin resistance.
3rd trimester
Safe. Critical for preventing macrosomia, shoulder dystocia, and neonatal hypoglycemia. Adjust doses as delivery approaches.
Clinical note
Gold standard for managing diabetes in pregnancy (Type 1, Type 2, and GDM). Does not cross the placenta. Provides precise titration with no teratogenic potential. Insulin analogs (aspart, lispro, detemir) have been shown safe in pregnancy. Glargine has less data but is used in practice. The only antidiabetic that does not cross the placenta.
Breastfeeding
Safe. Insulin is a natural component of breast milk and is well tolerated. Does not reach the infant circulation in meaningful amounts.
Warnings & precautions
When not to use it
Avoid in patients with known hypersensitivity to this drug or any of its components.
