Animal studies have proved adverse effects but may be safe for humans
How it works
Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.
Dosing & administration
Dosing varies by indication and patient profile. Always follow your institution's current prescribing guidelines.
Renal impairment
Consult protocols for adjustment.
Liver impairment
Consult protocols for adjustment.
Use during pregnancy
1st trimester
Caution. Use for specific cardiac indications; labetalol preferred for hypertension.
2nd trimester
Caution. Monitor fetal growth.
3rd trimester
Caution. Monitor neonate for bradycardia and hypoglycemia.
Clinical note
Beta-1 selective blocker used for hypertension and maternal cardiac conditions (arrhythmias, peripartum cardiomyopathy, thyrotoxicosis). Less well-studied than labetalol for obstetric hypertension, but no significant signal for major malformations. Associated with FGR to a lesser degree than atenolol. Use labetalol preferentially for uncomplicated hypertension; reserve metoprolol for specific cardiac indications.
Breastfeeding
Safe. Compatible with breastfeeding; low milk transfer.
