Piperacillin-Tazobactam | Drug Overview & Clinical Reference
Piperacillin-Tazobactam
Clinical safety rating: safe
Human studies have proved safety
How it works
Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.
Dosing & administration
Dosing varies by indication and patient profile. Always follow your institution's current prescribing guidelines.
Renal impairment
Consult protocols for adjustment.
Liver impairment
Consult protocols for adjustment.
Use during pregnancy
1st trimester
Safe. No teratogenic risk established.
2nd trimester
Safe.
3rd trimester
Safe. Standard of care for chorioamnionitis and postpartum endometritis.
Clinical note
Broad-spectrum beta-lactam/beta-lactamase inhibitor combination used IV for polymicrobial serious infections in pregnancy including chorioamnionitis, complicated UTI/pyelonephritis, and postpartum endometritis. No evidence of teratogenicity. Commonly used in obstetric practice for serious infections requiring broad coverage.
