PLASMA-LYTE 148 IN WATER IN PLASTIC CONTAINER
Clinical safety rating: caution
Comprehensive clinical and safety monograph for PLASMA-LYTE 148 IN WATER IN PLASTIC CONTAINER (PLASMA-LYTE 148 IN WATER IN PLASTIC CONTAINER).
Plasma-Lyte 148 is an isotonic crystalloid solution that provides electrolyte replacement and volume expansion. It mimics plasma electrolyte composition, with acetate and gluconate as bicarbonate precursors that are metabolized to bicarbonate in the liver and kidneys, helping to maintain acid-base balance.
| Metabolism | Acetate and gluconate are metabolized in the liver and kidneys to bicarbonate. Water and electrolytes are not metabolized but undergo renal excretion. |
| Excretion | Renal: >90% of infused electrolytes and water are excreted unchanged in urine. Biliary/fecal excretion is negligible (<1%). |
| Half-life | Not applicable; Plasma-Lyte 148 contains electrolytes and water that distribute according to body fluid compartments; infusion rate and renal function dictate elimination; clinical context: in normal renal function, excess fluids and electrolytes are cleared with a half-life of approximately 2-4 hours. |
| Protein binding | Not applicable; individual electrolytes do not bind to plasma proteins (e.g., sodium, chloride, potassium, magnesium, acetate, gluconate have negligible protein binding). |
| Volume of Distribution | Not applicable as a single value; electrolytes distribute into total body water (approximately 0.6 L/kg in adults); clinical meaning: initial distribution reflects extracellular fluid expansion. |
| Bioavailability | Intravenous: 100% (directly into systemic circulation). |
| Onset of Action | Intravenous: Immediate upon infusion; volume expansion and electrolyte effects occur within minutes. |
| Duration of Action | Intravenous: Duration depends on infusion rate and patient status; volume expansion lasts 1-2 hours after infusion stops; electrolyte effects persist until renal excretion; continuous infusion maintains steady state. |
Intravenous infusion; dose determined by electrolyte and fluid requirements. Typical adult rate: 25-100 mL/hour.
| Dosage form | INJECTABLE |
| Renal impairment | No specific dose adjustment; use with caution in renal impairment due to risk of electrolyte imbalances. Monitor serum electrolytes and renal function. |
| Liver impairment | No specific adjustment; use with caution in severe hepatic impairment due to potential for fluid and electrolyte disturbances. |
| Pediatric use | Intravenous infusion; dose based on weight and clinical status. Typical rate: 5-20 mL/kg/hour, adjust based on response. |
| Geriatric use | Use with caution due to potential for fluid overload and electrolyte disturbances; monitor renal function and adjust infusion rate accordingly. |
| 1st trimester | Consult provider |
| 2nd trimester | Consult provider |
| 3rd trimester | Consult provider |
Clinical note
Comprehensive clinical and safety monograph for PLASMA-LYTE 148 IN WATER IN PLASTIC CONTAINER (PLASMA-LYTE 148 IN WATER IN PLASTIC CONTAINER).
| Breastfeeding | Plasma-Lyte 148 components are endogenous and normally present in breast milk. No specific M/P ratio available; expected to be safe during lactation with usual clinical monitoring. |
| Teratogenic Risk | No fetal risks have been associated with Plasma-Lyte 148 in Water. It is an isotonic crystalloid solution containing electrolytes and water, lacking known teratogenic properties. No trimester-specific risks reported. |
| Fetal Monitoring |
■ FDA Black Box Warning
None
| Serious Effects |
["Hypersensitivity to any component","Severe renal impairment with oliguria or anuria","Hyperkalemia","Metabolic alkalosis","Clinically significant hypercalcemia","Patients with conditions where sodium retention is a concern (e.g., congestive heart failure, edema, cirrhosis)"]
| Precautions | ["Risk of fluid overload, especially in patients with heart failure or renal impairment","Electrolyte disturbances (hypernatremia, hyperkalemia, hypokalemia, hypercalcemia, hypermagnesemia) may occur","Monitor serum electrolytes, fluid balance, and renal function","Not recommended for use in patients with severe renal impairment or anuria","Use with caution in patients with metabolic alkalosis or conditions with predisposing factors for electrolyte imbalances"] |
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| Monitor maternal fluid and electrolyte balance, urine output, and signs of fluid overload during infusion. Fetal monitoring as per standard obstetric care if used during labor/delivery. |
| Fertility Effects | No known effects on fertility. Clinical data on reproductive impact are absent. |