Maternal-Fetal Safety

Pregnancy Registry

Evidence-based reference for medication safety during pregnancy and lactation. Verify FDA categories, trimester-specific risks, and breastfeeding compatibility.

Check Medication Safety

FDA Categories

Instant access to FDA pregnancy categories (A, B, C, D, X) for over 8,240 prescription agents.

Trimester Guidance

Specific clinical guidance for the first, second, and third trimesters of development.

Lactation Ratings

Briggs lactation ratings and breastfeeding safety notes for maternal pharmacology.

High Risk Alerts

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Contraindicated Agent	FDA Risk	Clinical Summary
ADAPALENE	Cat X	No major systemic drug interactions due to minimal absorption Use of abrasive soaps or cosmetics may cause significant irritation Avoid excessive sun exposure.
ADAPALENE AND BENZOYL PEROXIDE	Cat Contraindicated	No major systemic drug interactions due to minimal absorption Use of abrasive soaps or cosmetics may cause significant irritation Avoid excessive sun exposure.
AMIKACIN SULFATE	Cat X	Other nephrotoxic or ototoxic drugs like vancomycin or furosemide increase risk of toxicity Monitor peak and trough levels to minimize risk of nephrotoxicity and ototoxicity.
TELMISARTAN AND AMLODIPINE	Cat Contraindicated	NSAIDs may diminish the antihypertensive effect Lithium levels may be increased Use in pregnancy can cause injury and death to the developing fetus.
LEFLUNOMIDE	Cat X	Activated charcoal or cholestyramine can accelerate elimination Can cause hepatotoxicity and teratogenicity.
FENTANYL CITRATE	Cat Positive	CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.
DROSPIRENONE AND ETHINYL ESTRADIOL	Cat Positive	Inducers of CYP450 enzymes (eg carbamazepine) may decrease estrogen levels Increases risk of thromboembolic disorders and endometrial cancer.
MITOXANTRONE HYDROCHLORIDE	Cat X	Other cardiotoxic drugs increase risk Can cause severe myelosuppression and cardiotoxicity.
LOSARTAN POTASSIUM	Cat Contraindicated	NSAIDs may diminish the antihypertensive effect Lithium levels may be increased Use in pregnancy can cause injury and death to the developing fetus.
FLUOROURACIL	Cat X	Leucovorin enhances the toxicity and efficacy Can cause severe myelosuppression and mucositis.

Information provided here is for clinical reference only. Pregnancy safety data evolves rapidly; always consult the latest FDA labeling and maternal-fetal medicine specialists before making prescribing decisions.