OpiCalc

1386 Clinical Tools

OpiCalc

Easy, fast, and private medical tools for doctors. Always free.

Non-Custodial

bedside-Ready

Resources

About Us Editorial Policy Medical Disclaimer Privacy Policy Terms of Use Cookie Policy

Support

Response time:
Typically < 24 hours.

Clinical Notice:Calculations must be re-checked and should not be used alone to guide patient care, nor should they substitute for professional clinical judgment. OpiCalc is an auxiliary reference tool for qualified healthcare professionals.

OpiCalc © 2018-2026

•

All Rights Reserved

Validated • Peer-Reviewed • Instant

PROTAMINE SULFATE | Drug Overview & Clinical Reference

Antidote/Discontinued

PROTAMINE SULFATE

PROTAMINE SULFATE

Clinical safety rating: safe

Animal studies have demonstrated safety

How it works

Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.

Dosing & administration

Solution 10 mg/mL - Intravenous

Dosage form	Injectable
Renal impairment	Consult protocols for adjustment.
Liver impairment	Consult protocols for adjustment.

Use during pregnancy

1st trimester	Consult provider
2nd trimester	Consult provider
3rd trimester	Consult provider

Clinical note

No significant drug interactions Can cause severe hypotension and anaphylaxis.

Warnings & precautions

When not to use it

bradycardia

Drug interactions

Loading safety data…

This overview is compiled from peer-reviewed clinical sources and FDA labeling. It's here to support — not replace — clinical judgment. Always verify dosing against your institution's current protocols before prescribing.

On this page

How it works Dosing & administration Use during pregnancy Warnings & precautions Drug interactions

External sources

DailyMed (NIH) PubMed OpenFDA