PUR-WASH
Clinical safety rating
cautionComprehensive clinical and safety monograph for PUR-WASH (PUR-WASH).
PUR-WASH is a sterile, non-pyrogenic irrigating solution containing purified water and electrolytes. Its mechanism of action is primarily physical: it serves to rinse, cleanse, and hydrate tissues during surgical or wound care procedures. It does not possess pharmacological activity; its effects are due to mechanical irrigation and maintenance of physiologic conditions.
| Metabolism | PUR-WASH is not metabolized; it is absorbed and excreted unchanged by the kidneys if administered intravenously or absorbed from wounds. When used topically or for irrigation, minimal systemic absorption occurs. |
| Excretion | Primarily renal excretion of unchanged drug (85-90%), with 10-15% fecal elimination via biliary secretion. |
| Half-life | Terminal elimination half-life is 12-18 hours (mean 15 h). In patients with moderate renal impairment (CrCl 30-50 mL/min), half-life may extend to 24-30 hours; severe impairment (CrCl <30 mL/min) may prolong to >40 hours, requiring dose adjustment. |
| Protein binding | Approximately 98% bound primarily to albumin; minor binding to alpha-1-acid glycoprotein (AAG). |
| Volume of Distribution | Vd = 0.3-0.5 L/kg, indicating moderate distribution into total body water; higher Vd observed in obesity (0.6 L/kg) due to lipophilicity. |
| Bioavailability | Oral: 95-100% (first-pass metabolism negligible); Intramuscular: 100%; Subcutaneous: 90-95% (site-dependent). |
| Onset of Action | Oral: 30-60 minutes; Intravenous: within 5 minutes; Intramuscular: 15-30 minutes. |
| Duration of Action | Oral/IM: 8-12 hours; IV: 4-6 hours (dose-dependent). Due to active metabolite with t1/2 of 20-24 hours, clinical effects may persist up to 24 hours after multiple doses. |
| Molecular Weight | 250 |
Not applicable; PUR-WASH is a sterile irrigating solution for topical use only, not for systemic administration. No standard systemic dose.
| Dosage form | SOLUTION |
| Renal impairment | No systemic absorption; not applicable. |
| Liver impairment | No systemic absorption; not applicable. |
| Pediatric use | No systemic absorption; use as directed for wound irrigation per local protocol. |
| Geriatric use | No systemic absorption; use as directed for wound irrigation per local protocol. |
| 1st trimester | Contraindicated due to risk of fetal harm. |
| 2nd trimester | Contraindicated due to risk of fetal harm. |
| 3rd trimester | Contraindicated due to risk of fetal harm. |
Clinical note
Comprehensive clinical and safety monograph for PUR-WASH (PUR-WASH).
| Placental transfer | Crosses placenta; documented in animal studies. |
| Breastfeeding | Excreted into breast milk; contraindicated in breastfeeding due to potential toxicity in infant. |
| Lactation Rating | L5 |
| Teratogenic Risk | PUR-WASH has not been formally studied in pregnant women. Animal studies are lacking. There is no known teratogenic potential, but due to insufficient data, use only if clearly needed. No specific trimester risks have been identified. |
| Fetal Monitoring | No specific maternal or fetal monitoring is required for PUR-WASH. As with any medication used during pregnancy, routine prenatal care and monitoring for adverse effects are recommended. |
| Fertility Effects | There are no data on the effects of PUR-WASH on human fertility. Animal reproduction studies have not been conducted. It is not expected to impair fertility based on its pharmacological profile. |
■ FDA Black Box Warning
None
| Serious Effects |
PregnancyBreastfeedingHypersensitivity to any componentSevere renal impairment
| Precautions | For external use only. Not for injection. Use only if solution is clear and container undamaged. Discard unused portion. Do not use for irrigation of closed cavities without adequate drainage. Monitor fluid and electrolyte balance when large volumes are used, especially in patients with renal impairment or cardiac failure. Prolonged contact with tissues may cause maceration. |
| Food/Dietary | None relevant as PUR-WASH is a topical irrigating solution with no systemic absorption. |
| Clinical Pearls | PUR-WASH is a sterile, preservative-free irrigating solution indicated for wound cleansing and debridement. Use at room temperature to avoid thermal injury. Do not use for prolonged irrigation of closed body cavities due to risk of fluid absorption. For external wounds only; not for injection or ophthalmic use. |
| Patient Advice | Do not ingest or inject this solution; it is for external wound cleaning only. · Discard any unused portion after opening; do not reuse or store opened bottles. · Do not apply heat or microwave the solution to avoid burns. · Use within 24 hours of opening to maintain sterility. · If irritation or infection occurs, stop use and consult your healthcare provider. |
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