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Clinical Notice:Calculations must be re-checked and should not be used alone to guide patient care, nor should they substitute for professional clinical judgment. OpiCalc is an auxiliary reference tool for qualified healthcare professionals.

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PYRAZINAMIDE | Drug Overview & Clinical Reference

Antimycobacterial/Prescription

PYRAZINAMIDE

PYRAZINAMIDE

Clinical safety rating: safe

Animal studies have demonstrated safety

How it works

Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.

Dosing & administration

Tablet 500 mg - Oral

Dosage form	TABLET
Renal impairment	Consult protocols for adjustment.
Liver impairment	Consult protocols for adjustment.

Use during pregnancy

1st trimester	Consult provider
2nd trimester	Consult provider
3rd trimester	Consult provider

Clinical note

May increase uric acid levels Can cause hepatotoxicity and hyperuricemia.

Warnings & precautions

When not to use it

hyperuricemia

Drug interactions

Loading safety data…

This overview is compiled from peer-reviewed clinical sources and FDA labeling. It's here to support — not replace — clinical judgment. Always verify dosing against your institution's current protocols before prescribing.

On this page

How it works Dosing & administration Use during pregnancy Warnings & precautions Drug interactions

External sources

DailyMed (NIH) PubMed OpenFDA