Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.
Dosing & administration
Dosing varies by indication and patient profile. Always follow your institution's current prescribing guidelines.
Renal impairment
Consult protocols for adjustment.
Liver impairment
Consult protocols for adjustment.
Use during pregnancy
1st trimester
Caution. No consistent increase in MCM in large registries. Use when benefits outweigh risks.
2nd trimester
Caution. Monitor for gestational diabetes (GDM) due to metabolic effects.
3rd trimester
Caution. Monitor neonate for extrapyramidal symptoms (EPS), withdrawal, agitation, and feeding difficulties for 1–2 months after birth.
Clinical note
Atypical antipsychotic used for schizophrenia, bipolar disorder, and as an adjunct in treatment-resistant depression. Registry data and cohort studies involving thousands of first-trimester exposures do not demonstrate a consistent pattern of major congenital malformations. However, neonates exposed near delivery can develop extrapyramidal symptoms and neonatal withdrawal syndrome. Associated with gestational diabetes due to metabolic effects. Untreated psychosis or bipolar disorder in pregnancy carries serious maternal and fetal risks.
Breastfeeding
Caution. Excreted in breast milk; infant exposure is relatively low but monitor for sedation.
