Essential component of TB treatment (HRZE regimen) safe to use in pregnancy. No established teratogenicity at standard doses. At term, rifampicin induces fetal CYP enzymes and can deplete vitamin K-dependent clotting factors — administer prophylactic vitamin K (10 mg IM) to the neonate at birth if the mother was on rifampicin near delivery. Also a potent enzyme inducer that reduces levels of many coadministered drugs (e.g., reduces hormonal contraceptive efficacy).
How it works
Mechanism information is still being processed. Check the DailyMed link in the sidebar for the official prescribing information.
Dosing & administration
Dosing varies by indication and patient profile. Always follow your institution's current prescribing guidelines.
Renal impairment
Consult protocols for adjustment.
Liver impairment
Consult protocols for adjustment.
Use during pregnancy
1st trimester
Safe as part of TB regimen. No established teratogenicity.
2nd trimester
Safe.
3rd trimester
Safe. Administer vitamin K 10 mg IM to neonate at birth to prevent haemorrhagic disease of the newborn.
Clinical note
Essential component of TB treatment (HRZE regimen) safe to use in pregnancy. No established teratogenicity at standard doses. At term, rifampicin induces fetal CYP enzymes and can deplete vitamin K-dependent clotting factors — administer prophylactic vitamin K (10 mg IM) to the neonate at birth if the mother was on rifampicin near delivery. Also a potent enzyme inducer that reduces levels of many coadministered drugs (e.g., reduces hormonal contraceptive efficacy).
Breastfeeding
Caution. Excreted in breast milk; turns milk pink/orange (harmless). Compatible with breastfeeding.
Warnings & precautions
When not to use it
Avoid in patients with known hypersensitivity to this drug or any of its components.
