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Medication	Therapeutic Class	Generic Mapping	Safety
TOPAMAX Comprehensive clinical and safety monograph for TOPAMAX (TOPAMAX).	Anticonvulsant	TOPAMAX	caution
TOPAMAX SPRINKLE Comprehensive clinical and safety monograph for TOPAMAX SPRINKLE (TOPAMAX SPRINKLE).	Anticonvulsant	TOPAMAX SPRINKLE	caution
TOPICORT Comprehensive clinical and safety monograph for TOPICORT (TOPICORT).	Topical Corticosteroid	TOPICORT	caution
TOPICORT LP Comprehensive clinical and safety monograph for TOPICORT LP (TOPICORT LP).	Topical Corticosteroid	TOPICORT LP	caution
TOPICYCLINE Comprehensive clinical and safety monograph for TOPICYCLINE (TOPICYCLINE).	Topical Antibiotic (Tetracycline)	TOPICYCLINE	caution
TOPOSAR Comprehensive clinical and safety monograph for TOPOSAR (TOPOSAR).	Antineoplastic (Etoposide)	TOPOSAR	caution
TOPOTECAN Comprehensive clinical and safety monograph for TOPOTECAN (TOPOTECAN).	Antineoplastic (Topoisomerase Inhibitor)	TOPOTECAN	caution
TOPOTECAN HYDROCHLORIDE Comprehensive clinical and safety monograph for TOPOTECAN HYDROCHLORIDE (TOPOTECAN HYDROCHLORIDE).	Antineoplastic (Topoisomerase Inhibitor)	TOPOTECAN HYDROCHLORIDE	caution
TOPROL-XL Comprehensive clinical and safety monograph for TOPROL-XL (TOPROL-XL).	Beta-Blocker (Antihypertensive)	TOPROL-XL	caution
TORA Comprehensive clinical and safety monograph for TORA (TORA).	Diuretic (Loop Diuretic)	TORA	caution
TORADOL Comprehensive clinical and safety monograph for TORADOL (TORADOL).	NSAID (Ketorolac)	TORADOL	caution
TORECAN Comprehensive clinical and safety monograph for TORECAN (TORECAN).	Antiemetic	TORECAN	caution
TOREMIFENE CITRATE Comprehensive clinical and safety monograph for TOREMIFENE CITRATE (TOREMIFENE CITRATE).	Selective Estrogen Receptor Modulator	TOREMIFENE CITRATE	caution
TORISEL Comprehensive clinical and safety monograph for TORISEL (TORISEL).	mTOR Inhibitor	TORISEL	caution
TORNALATE Comprehensive clinical and safety monograph for TORNALATE (TORNALATE).	Bronchodilator	TORNALATE	caution
TORSEMIDE Other ototoxic drugs may increase risk of hearing loss NSAIDs may reduce the diuretic effect Profound diuresis and electrolyte depletion can occur.	Loop Diuretic	TORSEMIDE	safe
TOSYMRA Comprehensive clinical and safety monograph for TOSYMRA (TOSYMRA).	Antimigraine Agent	TOSYMRA	caution
TOTACILLIN Comprehensive clinical and safety monograph for TOTACILLIN (TOTACILLIN).	Penicillin Antibiotic	TOTACILLIN	caution
TOTACILLIN-N Comprehensive clinical and safety monograph for TOTACILLIN-N (TOTACILLIN-N).	Beta-Lactam Antibiotic Combination	TOTACILLIN-N	caution
TOTECT Comprehensive clinical and safety monograph for TOTECT (TOTECT).	Cardioprotective Agent	TOTECT	caution
TOUJEO MAX SOLOSTAR Comprehensive clinical and safety monograph for TOUJEO MAX SOLOSTAR (TOUJEO MAX SOLOSTAR).	Long-Acting Insulin	TOUJEO MAX SOLOSTAR	caution
TOUJEO SOLOSTAR Comprehensive clinical and safety monograph for TOUJEO SOLOSTAR (TOUJEO SOLOSTAR).	Long-Acting Insulin	TOUJEO SOLOSTAR	caution
TOVALT ODT Comprehensive clinical and safety monograph for TOVALT ODT (TOVALT ODT).	Atypical Antipsychotic	TOVALT ODT	caution
TOVIAZ Comprehensive clinical and safety monograph for TOVIAZ (TOVIAZ).	Antimuscarinic	TOVIAZ	caution
TPN Comprehensive clinical and safety monograph for TPN (TPN).	Parenteral Nutrition	TPN	caution
TPN ELECTROLYTES IN PLASTIC CONTAINER Comprehensive clinical and safety monograph for TPN ELECTROLYTES IN PLASTIC CONTAINER (TPN ELECTROLYTES IN PLASTIC CONTAINER).	Electrolyte Replacement	TPN ELECTROLYTES IN PLASTIC CONTAINER	caution
TPOXX Comprehensive clinical and safety monograph for TPOXX (TPOXX).	Antiviral Agent	TPOXX	caution
TRABECTEDIN Comprehensive clinical and safety monograph for TRABECTEDIN (TRABECTEDIN).	Antineoplastic Agent	TRABECTEDIN	caution
TRACLEER Comprehensive clinical and safety monograph for TRACLEER (TRACLEER).	Endothelin Receptor Antagonist	TRACLEER	caution
TRACRIUM Comprehensive clinical and safety monograph for TRACRIUM (TRACRIUM).	Neuromuscular Blocking Agent	TRACRIUM	caution
TRACRIUM PRESERVATIVE FREE Comprehensive clinical and safety monograph for TRACRIUM PRESERVATIVE FREE (TRACRIUM PRESERVATIVE FREE).	Neuromuscular Blocking Agent	TRACRIUM PRESERVATIVE FREE	caution
TRADJENTA Comprehensive clinical and safety monograph for TRADJENTA (TRADJENTA).	DPP-4 Inhibitor	TRADJENTA	caution
TRAL Comprehensive clinical and safety monograph for TRAL (TRAL).	Opioid Analgesic	TRAL	caution
TRALEMENT Comprehensive clinical and safety monograph for TRALEMENT (TRALEMENT).	Vitamin/Mineral Supplement	TRALEMENT	caution
Tramadol Avoid in pregnancy. Tramadol is a synthetic opioid and norepinephrine-serotonin reuptake inhibitor. Associated with Neonatal Opioid Withdrawal Syndrome (NOWS) and neonatal seizures when used near delivery. Contraindicated during breastfeeding (FDA 2017, same warning as codeine). No established teratogenicity at therapeutic doses but risk-benefit strongly favors alternatives.	Opioid Agonist		avoid
TRAMADOL HYDROCHLORIDE CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.	Opioid Agonist	TRAMADOL HYDROCHLORIDE	avoid
TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.	Opioid Agonist	TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN	avoid
TRAMETINIB DIMETHYL SULFOXIDE Comprehensive clinical and safety monograph for TRAMETINIB DIMETHYL SULFOXIDE (TRAMETINIB DIMETHYL SULFOXIDE).	MEK Inhibitor	TRAMETINIB DIMETHYL SULFOXIDE	caution
TRANCOPAL Comprehensive clinical and safety monograph for TRANCOPAL (TRANCOPAL).	Skeletal Muscle Relaxant	TRANCOPAL	caution
TRANDATE Comprehensive clinical and safety monograph for TRANDATE (TRANDATE).	Beta-Blocker	TRANDATE	caution
TRANDATE HCT Comprehensive clinical and safety monograph for TRANDATE HCT (TRANDATE HCT).	Antihypertensive Combination	TRANDATE HCT	caution
TRANDOLAPRIL NSAIDs may diminish the antihypertensive effect Lithium levels may be increased Risk of angioedema can occur at any time discontinue immediately.	ACE Inhibitor	TRANDOLAPRIL	avoid
TRANDOLAPRIL AND VERAPAMIL HYDROCHLORIDE CYP3A4 inhibitors can increase levels and inducers can decrease levels Can cause bradycardia and heart failure.	Non-Dihydropyridine CCB	TRANDOLAPRIL AND VERAPAMIL HYDROCHLORIDE	safe
TRANEXAMIC ACID No significant drug interactions Can cause thrombosis and visual disturbances.	Antifibrinolytic	TRANEXAMIC ACID	safe
TRANMEP Comprehensive clinical and safety monograph for TRANMEP (TRANMEP).	Anxiolytic	TRANMEP	caution
TRANSDERM SCOP Comprehensive clinical and safety monograph for TRANSDERM SCOP (TRANSDERM SCOP).	Antiemetic	TRANSDERM SCOP	caution
TRANSDERM-NITRO Comprehensive clinical and safety monograph for TRANSDERM-NITRO (TRANSDERM-NITRO).	Vasodilator	TRANSDERM-NITRO	caution
TRANXENE Comprehensive clinical and safety monograph for TRANXENE (TRANXENE).	Benzodiazepine Anxiolytic	TRANXENE	caution
TRANXENE SD Comprehensive clinical and safety monograph for TRANXENE SD (TRANXENE SD).	Benzodiazepine Anxiolytic	TRANXENE SD	caution
TRANYLCYPROMINE SULFATE Comprehensive clinical and safety monograph for TRANYLCYPROMINE SULFATE (TRANYLCYPROMINE SULFATE).	MAOI Antidepressant	TRANYLCYPROMINE SULFATE	caution

TOPAMAX

Comprehensive clinical and safety monograph for TOPAMAX (TOPAMAX).

Anticonvulsant

caution

TOPAMAX SPRINKLE

Comprehensive clinical and safety monograph for TOPAMAX SPRINKLE (TOPAMAX SPRINKLE).

Anticonvulsant

caution

TOPICORT

Comprehensive clinical and safety monograph for TOPICORT (TOPICORT).

Topical Corticosteroid

caution

TOPICORT LP

Comprehensive clinical and safety monograph for TOPICORT LP (TOPICORT LP).

Topical Corticosteroid

caution

TOPICYCLINE

Comprehensive clinical and safety monograph for TOPICYCLINE (TOPICYCLINE).

Topical Antibiotic (Tetracycline)

caution

TOPOSAR

Comprehensive clinical and safety monograph for TOPOSAR (TOPOSAR).

Antineoplastic (Etoposide)

caution

TOPOTECAN

Comprehensive clinical and safety monograph for TOPOTECAN (TOPOTECAN).

Antineoplastic (Topoisomerase Inhibitor)

caution

TOPOTECAN HYDROCHLORIDE

Comprehensive clinical and safety monograph for TOPOTECAN HYDROCHLORIDE (TOPOTECAN HYDROCHLORIDE).

Antineoplastic (Topoisomerase Inhibitor)

caution

TOPROL-XL

Comprehensive clinical and safety monograph for TOPROL-XL (TOPROL-XL).

Beta-Blocker (Antihypertensive)

caution

TORA

Comprehensive clinical and safety monograph for TORA (TORA).

Diuretic (Loop Diuretic)

caution

TORADOL

Comprehensive clinical and safety monograph for TORADOL (TORADOL).

NSAID (Ketorolac)

caution

TORECAN

Comprehensive clinical and safety monograph for TORECAN (TORECAN).

Antiemetic

caution

TOREMIFENE CITRATE

Comprehensive clinical and safety monograph for TOREMIFENE CITRATE (TOREMIFENE CITRATE).

Selective Estrogen Receptor Modulator

caution

TORISEL

Comprehensive clinical and safety monograph for TORISEL (TORISEL).

mTOR Inhibitor

caution

TORNALATE

Comprehensive clinical and safety monograph for TORNALATE (TORNALATE).

Bronchodilator

caution

TORSEMIDE

Other ototoxic drugs may increase risk of hearing loss NSAIDs may reduce the diuretic effect Profound diuresis and electrolyte depletion can occur.

Loop Diuretic

safe

TOSYMRA

Comprehensive clinical and safety monograph for TOSYMRA (TOSYMRA).

Antimigraine Agent

caution

TOTACILLIN

Comprehensive clinical and safety monograph for TOTACILLIN (TOTACILLIN).

Penicillin Antibiotic

caution

TOTACILLIN-N

Comprehensive clinical and safety monograph for TOTACILLIN-N (TOTACILLIN-N).

Beta-Lactam Antibiotic Combination

caution

TOTECT

Comprehensive clinical and safety monograph for TOTECT (TOTECT).

Cardioprotective Agent

caution

TOUJEO MAX SOLOSTAR

Comprehensive clinical and safety monograph for TOUJEO MAX SOLOSTAR (TOUJEO MAX SOLOSTAR).

Long-Acting Insulin

caution

TOUJEO SOLOSTAR

Comprehensive clinical and safety monograph for TOUJEO SOLOSTAR (TOUJEO SOLOSTAR).

Long-Acting Insulin

caution

TOVALT ODT

Comprehensive clinical and safety monograph for TOVALT ODT (TOVALT ODT).

Atypical Antipsychotic

caution

TOVIAZ

Comprehensive clinical and safety monograph for TOVIAZ (TOVIAZ).

Antimuscarinic

caution

TPN

Comprehensive clinical and safety monograph for TPN (TPN).

Parenteral Nutrition

caution

TPN ELECTROLYTES IN PLASTIC CONTAINER

Comprehensive clinical and safety monograph for TPN ELECTROLYTES IN PLASTIC CONTAINER (TPN ELECTROLYTES IN PLASTIC CONTAINER).

Electrolyte Replacement

caution

TPOXX

Comprehensive clinical and safety monograph for TPOXX (TPOXX).

Antiviral Agent

caution

TRABECTEDIN

Comprehensive clinical and safety monograph for TRABECTEDIN (TRABECTEDIN).

Antineoplastic Agent

caution

TRACLEER

Comprehensive clinical and safety monograph for TRACLEER (TRACLEER).

Endothelin Receptor Antagonist

caution

TRACRIUM

Comprehensive clinical and safety monograph for TRACRIUM (TRACRIUM).

Neuromuscular Blocking Agent

caution

TRACRIUM PRESERVATIVE FREE

Comprehensive clinical and safety monograph for TRACRIUM PRESERVATIVE FREE (TRACRIUM PRESERVATIVE FREE).

Neuromuscular Blocking Agent

caution

TRADJENTA

Comprehensive clinical and safety monograph for TRADJENTA (TRADJENTA).

DPP-4 Inhibitor

caution

TRAL

Comprehensive clinical and safety monograph for TRAL (TRAL).

Opioid Analgesic

caution

TRALEMENT

Comprehensive clinical and safety monograph for TRALEMENT (TRALEMENT).

Vitamin/Mineral Supplement

caution

Tramadol

Avoid in pregnancy. Tramadol is a synthetic opioid and norepinephrine-serotonin reuptake inhibitor. Associated with Neonatal Opioid Withdrawal Syndrome (NOWS) and neonatal seizures when used near delivery. Contraindicated during breastfeeding (FDA 2017, same warning as codeine). No established teratogenicity at therapeutic doses but risk-benefit strongly favors alternatives.

Opioid Agonist

avoid

TRAMADOL HYDROCHLORIDE

CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.

Opioid Agonist

avoid

TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN

CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.

Opioid Agonist

avoid

TRAMETINIB DIMETHYL SULFOXIDE

Comprehensive clinical and safety monograph for TRAMETINIB DIMETHYL SULFOXIDE (TRAMETINIB DIMETHYL SULFOXIDE).

MEK Inhibitor

caution

TRANCOPAL

Comprehensive clinical and safety monograph for TRANCOPAL (TRANCOPAL).

Skeletal Muscle Relaxant

caution

TRANDATE

Comprehensive clinical and safety monograph for TRANDATE (TRANDATE).

Beta-Blocker

caution

TRANDATE HCT

Comprehensive clinical and safety monograph for TRANDATE HCT (TRANDATE HCT).

Antihypertensive Combination

caution

TRANDOLAPRIL

NSAIDs may diminish the antihypertensive effect Lithium levels may be increased Risk of angioedema can occur at any time discontinue immediately.

ACE Inhibitor

avoid

TRANDOLAPRIL AND VERAPAMIL HYDROCHLORIDE

CYP3A4 inhibitors can increase levels and inducers can decrease levels Can cause bradycardia and heart failure.

Non-Dihydropyridine CCB

safe

TRANEXAMIC ACID

No significant drug interactions Can cause thrombosis and visual disturbances.

Antifibrinolytic

safe

TRANMEP

Comprehensive clinical and safety monograph for TRANMEP (TRANMEP).

Anxiolytic

caution

TRANSDERM SCOP

Comprehensive clinical and safety monograph for TRANSDERM SCOP (TRANSDERM SCOP).

Antiemetic

caution

TRANSDERM-NITRO

Comprehensive clinical and safety monograph for TRANSDERM-NITRO (TRANSDERM-NITRO).

Vasodilator

caution

TRANXENE

Comprehensive clinical and safety monograph for TRANXENE (TRANXENE).

Benzodiazepine Anxiolytic

caution

TRANXENE SD

Comprehensive clinical and safety monograph for TRANXENE SD (TRANXENE SD).

Benzodiazepine Anxiolytic

caution

TRANYLCYPROMINE SULFATE

Comprehensive clinical and safety monograph for TRANYLCYPROMINE SULFATE (TRANYLCYPROMINE SULFATE).

MAOI Antidepressant

caution

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