8,240 Clinical Drug Overviews
COBENFY
Comprehensive clinical and safety monograph for COBENFY (COBENFY).
SGLT2 Inhibitor Antidiabetic
COBICISTAT
Comprehensive clinical and safety monograph for COBICISTAT (COBICISTAT).
Pharmacokinetic Enhancer
CODAMINE
Comprehensive clinical and safety monograph for CODAMINE (CODAMINE).
Opioid Analgesic Combination
Codeine
Avoid. Codeine is a prodrug converted by CYP2D6 to morphine. Ultra-rapid metabolizers produce excessive morphine, posing risk of neonatal opioid toxicity. In 2017, the FDA contraindicated codeine (and tramadol) for breastfeeding mothers due to neonatal deaths from morphine toxicity in infants of ultra-rapid metabolizers. In pregnancy, opioids carry risk of Neonatal Opioid Withdrawal Syndrome (NOWS), fetal growth restriction, and preterm birth with chronic use. For acute pain in pregnancy, acetaminophen is preferred. Short-term use of codeine near term poses additional risk of neonatal respiratory depression.
Opioid Agonist
CODEINE SULFATE
CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.
CODEINE, ASPIRIN, APAP FORMULA NO. 2
CODEINE, ASPIRIN, APAP FORMULA NO. 3
CODEINE, ASPIRIN, APAP FORMULA NO. 4
CODEPREX
Comprehensive clinical and safety monograph for CODEPREX (CODEPREX).
Antitussive Combination
CODIMAL-L.A. 12
Comprehensive clinical and safety monograph for CODIMAL-L.A. 12 (CODIMAL-L.A. 12).
Cold & Cough Combination
CODOXY
Comprehensive clinical and safety monograph for CODOXY (CODOXY).
CODRIX
Comprehensive clinical and safety monograph for CODRIX (CODRIX).
COGENTIN
Comprehensive clinical and safety monograph for COGENTIN (COGENTIN).
Anticholinergic Antiparkinsonian
COGNEX
Comprehensive clinical and safety monograph for COGNEX (COGNEX).
Cholinesterase Inhibitor
COL-PROBENECID
Increases levels of many drugs by inhibiting their renal secretion (eg penicillins methotrexate) Can cause GI upset and nephrotic syndrome.
Uricosuric
COLAZAL
Comprehensive clinical and safety monograph for COLAZAL (COLAZAL).
5-Aminosalicylate
COLBENEMID
Comprehensive clinical and safety monograph for COLBENEMID (COLBENEMID).
Antigout Agent Combination
COLCHICINE
Strong CYP3A4 or P-gp inhibitors (eg clarithromycin) dramatically increase levels and risk of fatal toxicity Can cause myelosuppression with chronic use.
Antigout
COLCRYS
Comprehensive clinical and safety monograph for COLCRYS (COLCRYS).
Antigout Agent
COLD CAPSULE IV
Comprehensive clinical and safety monograph for COLD CAPSULE IV (COLD CAPSULE IV).
COLD CAPSULE V
Comprehensive clinical and safety monograph for COLD CAPSULE V (COLD CAPSULE V).
COLESEVELAM HYDROCHLORIDE
Can decrease the absorption of many other drugs (eg warfarin phenytoin) administer other drugs 4 hours before colesevelam Can cause constipation and may increase triglycerides.
Bile Acid Sequestrant
COLESTID
Comprehensive clinical and safety monograph for COLESTID (COLESTID).
COLESTIPOL HYDROCHLORIDE
Comprehensive clinical and safety monograph for COLESTIPOL HYDROCHLORIDE (COLESTIPOL HYDROCHLORIDE).
COLGATE TOTAL
Comprehensive clinical and safety monograph for COLGATE TOTAL (COLGATE TOTAL).
Dental Product
COLISTIMETHATE SODIUM
Comprehensive clinical and safety monograph for COLISTIMETHATE SODIUM (COLISTIMETHATE SODIUM).
Polymyxin Antibiotic
COLOCORT
Comprehensive clinical and safety monograph for COLOCORT (COLOCORT).
Corticosteroid
COLONAID
Comprehensive clinical and safety monograph for COLONAID (COLONAID).
Laxative
COLOVAGE
Comprehensive clinical and safety monograph for COLOVAGE (COLOVAGE).
Osmotic Laxative
COLPREP KIT
Comprehensive clinical and safety monograph for COLPREP KIT (COLPREP KIT).
COLUMVI
Comprehensive clinical and safety monograph for COLUMVI (COLUMVI).
Antineoplastic Agent (Monoclonal Antibody)
COLY-MYCIN M
Comprehensive clinical and safety monograph for COLY-MYCIN M (COLY-MYCIN M).
COLY-MYCIN S
Comprehensive clinical and safety monograph for COLY-MYCIN S (COLY-MYCIN S).
COLYTE
Comprehensive clinical and safety monograph for COLYTE (COLYTE).
COLYTE WITH FLAVOR PACKS
Comprehensive clinical and safety monograph for COLYTE WITH FLAVOR PACKS (COLYTE WITH FLAVOR PACKS).
COLYTE-FLAVORED
Comprehensive clinical and safety monograph for COLYTE-FLAVORED (COLYTE-FLAVORED).
COMBIGAN
Comprehensive clinical and safety monograph for COMBIGAN (COMBIGAN).
Ophthalmic Antiglaucoma Agent (Alpha-2 Agonist + Beta Blocker)
COMBIPATCH
Comprehensive clinical and safety monograph for COMBIPATCH (COMBIPATCH).
Hormone Replacement Therapy (Estrogen/Progestin)
COMBIPRES
Comprehensive clinical and safety monograph for COMBIPRES (COMBIPRES).
Antihypertensive Combination (ACE Inhibitor + Calcium Channel Blocker)
COMBIVENT
Comprehensive clinical and safety monograph for COMBIVENT (COMBIVENT).
Bronchodilator Combination (Anticholinergic + Beta-2 Agonist)
COMBIVENT RESPIMAT
Comprehensive clinical and safety monograph for COMBIVENT RESPIMAT (COMBIVENT RESPIMAT).
COMBIVIR
Comprehensive clinical and safety monograph for COMBIVIR (COMBIVIR).
Antiretroviral (NRTI Combination)
COMBOGESIC
Comprehensive clinical and safety monograph for COMBOGESIC (COMBOGESIC).
Analgesic Combination (Opioid + Non-Opioid)
COMBOGESIC IV
Comprehensive clinical and safety monograph for COMBOGESIC IV (COMBOGESIC IV).
COMBUNOX
Comprehensive clinical and safety monograph for COMBUNOX (COMBUNOX).
Analgesic Combination (Opioid + NSAID)
COMETRIQ
Comprehensive clinical and safety monograph for COMETRIQ (COMETRIQ).
Antineoplastic (Multikinase Inhibitor)
COMPAZINE
Comprehensive clinical and safety monograph for COMPAZINE (COMPAZINE).
Antipsychotic (Phenothiazine) / Antiemetic
COMPLERA
Comprehensive clinical and safety monograph for COMPLERA (COMPLERA).
Antiretroviral (NRTI + NNRTI Combination)
COMPOUND 65
Comprehensive clinical and safety monograph for COMPOUND 65 (COMPOUND 65).
COMPRO
Comprehensive clinical and safety monograph for COMPRO (COMPRO).
Antiemetic
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