Diagnosis Protocol

Asymptomatic. Persistent generalised lymphadenopathy. Performance Scale 1: asymptomatic, normal activity.

Moderate unexplained weight loss (< 10%). Minor mucocutaneous manifestations (seborrheic dermatitis, pruritic eruptions, fungal nail infections, recurrent oral ulcerations, angular cheilitis). Herpes zoster. Recurrent upper respiratory tract infections. Performance scale 2: symptomatic but normal activity.

Unexplained severe weight loss (> 10%). Unexplained chronic diarrhoea for > 1 month. Unexplained persistent fever for > 1 month. Persistent oral candidiasis. Oral hairy leukoplakia. Pulmonary tuberculosis. Severe bacterial infections. Acute necrotizing ulcerative stomatitis. Unexplained anaemia (< 8 g/dl), neutropenia (< 0.5x10^9/L), chronic thrombocytopenia (< 50x10^9/L). Performance scale 3: Bed ridden for < 50% of the day during the last month.

HIV wasting syndrome. Pneumocystis jirovecii pneumonia (PCP). Toxoplasmosis of the brain. Cryptosporidiosis with diarrhoea for > 1 month. Extrapulmonary cryptococcosis including meningitis. Cytomegalovirus infection. Chronic oro-labial, genital or ano-rectal HSV for > 1 month. Progressive multifocal leukoencephalopathy (PML). Disseminated endemic mycosis. Candidiasis of oesophagus/trachea/bronchi/lungs. Disseminated non-tuberculous mycobacterial infection. Recurrent septicaemia. Extrapulmonary TB. Lymphoma. Invasive cervical cancer. Kaposi sarcoma. HIV encephalopathy. Symptomatic HIV-associated nephropathy or cardiomyopathy. Performance scale 4: Bed-ridden for > 50% of the day.